Academic Journal
Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells
| العنوان: | Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells |
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| المؤلفون: | Rozanski, Cheryl H., Arens, Ramon, Carlson, Louise M., Nair, Jayakumar, Boise, Lawrence H., Chanan-Khan, Asher A., Schoenberger, Stephen P., Lee, Kelvin P. |
| المصدر: | Journal of Experimental Medicine ; volume 208, issue 7, page 1435-1446 ; ISSN 1540-9538 0022-1007 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2011 |
| الوصف: | Sustained long-term antibody levels are the cornerstone of protective immunity, yet it remains unclear how they are durably maintained. A predominant theory implicates antigen-independent antibody production by a subset of long-lived plasma cells (LLPCs) that survive within bone marrow (BM). Central tenets of this model—that BM LLPCs constitute a subset defined by intrinsic biology distinct from PCs in other tissues and contribute to long-term antibody titers—have not been definitively demonstrated. We now report that long-term humoral immunity depends on the PC-intrinsic function of CD28, which selectively supports the survival of BM LLPC but not splenic short-lived PC (SLPC). LLPC and SLPC both express CD28, but CD28-driven enhanced survival occurred only in the LLPC. In vivo, even in the presence of sufficient T cell help, loss of CD28 or its ligands CD80 and CD86 caused significant loss of the LLPC population, reduction of LLPC half-life from 426 to 63 d, and inability to maintain long-term antibody titers, but there was no effect on SLPC populations. These findings establish the existence of the distinct BM LLPC subset necessary to sustain antibody titers and uncover a central role for CD28 function in the longevity of PCs and humoral immunity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20110040 |
| الاتاحة: | http://dx.doi.org/10.1084/jem.20110040 https://rupress.org/jem/article-pdf/208/7/1435/1741943/jem_20110040.pdf |
| رقم الانضمام: | edsbas.A06D999B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20110040 |
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