Academic Journal

Effect of a novel stobadine derivative on isolated rat arteries

التفاصيل البيبلوغرافية
العنوان: Effect of a novel stobadine derivative on isolated rat arteries
المؤلفون: Broskova, Zuzana, Sotnikova, Ruzena, Nedelcevova, Jana, Bagi, Zsolt
المصدر: Interdisciplinary Toxicology ; volume 6, issue 2, page 63-66 ; ISSN 1337-9569 1337-6853
بيانات النشر: Walter de Gruyter GmbH
سنة النشر: 2013
الوصف: The antioxidant and reactive-oxygen-species-scavenging activity of stobadine has been demonstrated in previous studies. Recently, chemical modification of this leading structure led to the synthesis of other pyridoindole derivatives with significantly increased intrinsic antioxidant efficacy. Further structural modifications of stobadine provided the opportunity to increase bioavailability and attenuate unwanted side effects, such as α-adrenolytic activity. The aim of the work was to evaluate the direct effect of a novel pyridoindole, SMe1EC2, on the vascular wall ex vivo. The vasomotor effect of SMe1EC2 (1×10 -8 -1×10 -4 mol/l) was measured on isolated and pressurized rat cerebral and coronary arterioles using video-microscopy. The effect of SMe1EC2 (1×10 -6 and 1×10 -5 mol/l) on high potassium-, phenylephrine- or serotonin-induced contraction or acetylcholine-induced relaxation was also determined in aortic rings. We found that SMe1EC2 (1×10 -8 -1×10 -4 mol/l) elicited significant dilatations in both cerebral and coronary arterioles (max dilatation: 25±8% and 18±5% respectively). Yet, SMe1EC2 (1×10 -6 and 1×10 -5 mol/l) did not influence the tone of aortic rings nor did it affect high potassium-, phenylephrine- or serotonin -induced contractions and acetylcholine-induced relaxation. Thus SMe1EC2 was able to dilate resistance arteries but did not affect aortic contractility. It is likely that SMe1EC2 does not possess α1-adrenolytic and anti-serotoninergic activity in the vascular wall.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
DOI: 10.2478/intox-2013-0011
الاتاحة: http://dx.doi.org/10.2478/intox-2013-0011
http://content.sciendo.com/view/journals/intox/6/2/article-p63.xml
https://www.degruyter.com/view/j/intox.2013.6.issue-2/intox-2013-0011/intox-2013-0011.pdf
رقم الانضمام: edsbas.9FCB2D8D
قاعدة البيانات: BASE