التفاصيل البيبلوغرافية
| العنوان: |
Sex Hormones, Growth Hormone, and the Cornea |
| المؤلفون: |
McKay, Tina B., Priyadarsini, Shrestha, Karamichos, Dimitrios |
| المصدر: |
Cells |
| بيانات النشر: |
MDPI |
| سنة النشر: |
2022 |
| المجموعة: |
UNTHSC Scholarly Repository (University. of North Texas Health Science Center) |
| مصطلحات موضوعية: |
cornea, estradiol, estrogen, growth hormone, insulin growth factor-1, wound healing, Animals, Cornea / metabolism, Gonadal Steroid Hormones / chemistry, Gonadal Steroid Hormones / metabolism, Growth Hormone / metabolism, Humans, Receptors, Cell Surface / metabolism |
| الوصف: |
The growth and maintenance of nearly every tissue in the body is influenced by systemic hormones during embryonic development through puberty and into adulthood. Of the ~130 different hormones expressed in the human body, steroid hormones and peptide hormones are highly abundant in circulation and are known to regulate anabolic processes and wound healing in a tissue-dependent manner. Of interest, differential levels of sex hormones have been associated with ocular pathologies, including dry eye disease and keratoconus. In this review, we discuss key studies that have revealed a role for androgens and estrogens in the cornea with focus on ocular surface homeostasis, wound healing, and stromal thickness. We also review studies of human growth hormone and insulin growth factor-1 in influencing ocular growth and epithelial regeneration. While it is unclear if endogenous hormones contribute to differential corneal wound healing in common animal models, the abundance of evidence suggests that systemic hormone levels, as a function of age, should be considered as an experimental variable in studies of corneal health and disease. ; This research was funded by the National Institutes of Health and National Eye Institute, grant number EY028888 (DK). |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| تدمد: |
2073-4409 |
| Relation: |
https://doi.org/10.3390/cells11020224; McKay, T. B., Priyadarsini, S., & Karamichos, D. (2022). Sex Hormones, Growth Hormone, and the Cornea. Cells, 11(2), 224. https://doi.org/10.3390/cells11020224; https://hdl.handle.net/20.500.12503/31795; 11 |
| الاتاحة: |
https://hdl.handle.net/20.500.12503/31795 |
| Rights: |
Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ ; © 2022 by the authors. |
| رقم الانضمام: |
edsbas.9FB6FC75 |
| قاعدة البيانات: |
BASE |
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