Academic Journal
The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia
| العنوان: | The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia |
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| المؤلفون: | Falzoni, Simonetta, Vultaggio-Poma, Valentina, Chiozzi, Paola, Tarantini, Mario, Adinolfi, Elena, Boldrini, Paola, Giuliani, Anna Lisa, Morciano, Giampaolo, Tang, Yong, Gorecki, Dariusz C, Di Virgilio, Francesco |
| المساهمون: | Falzoni, Simonetta, Vultaggio-Poma, Valentina, Chiozzi, Paola, Tarantini, Mario, Adinolfi, Elena, Boldrini, Paola, Giuliani, Anna Lisa, Morciano, Giampaolo, Tang, Yong, Gorecki, Dariusz C, Di Virgilio, Francesco |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| مصطلحات موضوعية: | P2X7 receptor, inflammation, microglia, microparticles, mitochondria |
| الوصف: | Microparticles (MPs) are secreted by all cells, where they play a key role in intercellular communication, differentiation, inflammation, and cell energy transfer. P2X7 receptor (P2X7R) activation by extracellular ATP (eATP) causes a large MP release and affects their contents in a cell-specific fashion. We investigated MP release and functional impact in microglial cells from P2X7R-WT or P2X7R-KO mice, as well as mouse microglial cell lines characterized for high (N13-P2X7RHigh) or low (N13-P2X7RLow) P2X7R expression. P2X7R stimulation promoted release of a mixed MP population enriched with naked mitochondria. Released mitochondria were taken up and incorporated into the mitochondrial network of the recipient cells in a P2X7R-dependent fashion. NLRP3 and the P2X7R itself were also delivered to the recipient cells. Microparticle transfer increased the energy level of the recipient cells and conferred a pro-inflammatory phenotype. These data show that the P2X7R is a master regulator of intercellular organelle and MP trafficking in immune cells.Graphical Abstract |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38984997; info:eu-repo/semantics/altIdentifier/wos/WOS:001267265600002; volume:5; issue:4; firstpage:zqae019-1; lastpage:zqae019-16; numberofpages:16; journal:FUNCTION; https://hdl.handle.net/11392/2570732; https://academic.oup.com/function/article/5/4/zqae019/7649358 |
| DOI: | 10.1093/function/zqae019 |
| الاتاحة: | https://hdl.handle.net/11392/2570732 https://doi.org/10.1093/function/zqae019 https://academic.oup.com/function/article/5/4/zqae019/7649358 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9F8C7CE6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/function/zqae019 |
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