Academic Journal
MG53: Biological Function and Potential as a Therapeutic Target
| العنوان: | MG53: Biological Function and Potential as a Therapeutic Target |
|---|---|
| المؤلفون: | Zhang, Yan, Wu, Hong-Kun, Lv, Fengxiang, Xiao, Rui-Ping |
| المساهمون: | Zhang, Y (reprint author), Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China., Peking Univ, Inst Mol Med, State Key Lab Membrane Biol, Beijing, Peoples R China., Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China., Peking Univ, Beijing City Key Lab Cardiometabol Mol Med, Beijing, Peoples R China., Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | MOLECULAR PHARMACOLOGY |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | ISCHEMIA-REPERFUSION INJURY, CELL-MEMBRANE REPAIR, INSULIN-RECEPTOR SUBSTRATE-1, E3 UBIQUITIN LIGASES, SKELETAL-MUSCLE, MUSCULAR-DYSTROPHY, METABOLIC SYNDROME, MOLECULAR REGULATION, SIGNALING PATHWAY, MYOCARDIAL INJURY |
| الوصف: | MG53 (also known as tripartite motif, TRIM72) is a cardiac and skeletal muscle-specific TRIM-family protein that exhibits multiple biologic functions. First, MG53 participates in plasma membrane repair of the heart, skeletal muscle, and, other tissues. Second, MG53 is essentially involved in the cardioprotection of cardiac ischemic, preconditioning, and postconditioning by activating the PI3K-Akt-GSK3b and ERK1/2 survival signaling pathways. Moreover, systemic delivery of recombinant MG53 protein ameliorates the impact of a range of injury insults on the heart, skeletal muscle, lung, kidney, skin, and brain. It is noteworthy that chronic upregulation of MG53 induces insulin resistance and metabolic diseases, such as type 2 diabetes and its cardiovascular complications, by acting as an E3 ligase to mediate the degradation of insulin receptor and insulin receptor substrate-1. In addition, MG53 negatively regulates myogenesis. In summary, MG53 is a multifunctional protein involved in the vital physiologic and pathologic processes of multiple organs and is a promising therapeutic target for various human diseases. In this review, we comprehensively summarize current research progress on the biologic functions and therapeutic potential of MG53. ; National Basic Research Program of China [2013CB531200, 2012CB518000]; National Natural Science Foundation of China [31671177, 81170100, 81370234, 81630008, 81270190, 31521062]; National Science and Technology Major Projects for Major New Drugs Innovation and Development [2013ZX09508104] ; SCI(E) ; REVIEW ; 3 ; 211-218 ; 92 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0026-895X 1521-0111 |
| Relation: | MOLECULAR PHARMACOLOGY.2017,92(3),211-218.; 1905317; http://hdl.handle.net/20.500.11897/471254; WOS:000407697200005 |
| DOI: | 10.1124/mol.117.108241 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/471254 https://doi.org/10.1124/mol.117.108241 |
| رقم الانضمام: | edsbas.9F731FAC |
| قاعدة البيانات: | BASE |
| تدمد: | 0026895X 15210111 |
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| DOI: | 10.1124/mol.117.108241 |