Academic Journal
A HIGHLY CONSERVED PERICENTROMERIC DOMAIN IN HUMAN AND GORILLA CHROMOSOMES
| العنوان: | A HIGHLY CONSERVED PERICENTROMERIC DOMAIN IN HUMAN AND GORILLA CHROMOSOMES |
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| المؤلفون: | M. PITA, J. GOSALVEZ, A. GOSALVEZ, C. LOPEZ FERNANDEZ, R. MEZZANOTTE, NIEDDU, MARIELLA |
| المساهمون: | M., Pita, J., Gosalvez, A., Gosalvez, Nieddu, Mariella, C., LOPEZ FERNANDEZ, R., Mezzanotte |
| سنة النشر: | 2009 |
| المجموعة: | Università degli Studi di Cagliari: UNICA IRIS |
| الوصف: | Significant similarity between human and gorilla genomes has been found in all chromosome arms, but not in centromeres, using whole-comparative genomic hybridization (W-CGH). In human chromosomes, centromeric regions, generally containing highly repetitive DNAs, are characterized by the presence of specific human DNA sequences and an absence of homology with gorilla DNA sequences. The only exception is the pericentromeric area of human chromosome 9, which, in addition to a large block of human DNA, also contains a region of homology with gorilla DNA sequences; the localization of these sequences coincides with that of human satellite III. Since highly repetitive DNAs are known for their high mutation frequency, we hypothesized that the chromosome 9 pericentromeric DNA conserved in human chromosomes and deriving from the gorilla genome may thus play some important functional role. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/20068296; info:eu-repo/semantics/altIdentifier/wos/WOS:000273545100003; volume:126; firstpage:253; lastpage:258; numberofpages:6; journal:CYTOGENETIC AND GENOME RESEARCH; http://hdl.handle.net/11584/23092; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-75449095853 |
| DOI: | 10.1159/000251962 |
| الاتاحة: | http://hdl.handle.net/11584/23092 https://doi.org/10.1159/000251962 |
| رقم الانضمام: | edsbas.9F5B6549 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000251962 |
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