Academic Journal
P048 Herpes Zoster Incidence in Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study
| العنوان: | P048 Herpes Zoster Incidence in Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study |
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| المؤلفون: | Stempniewicz, Nikita, Steffens, Andrea, Kim, Kimvi, Jorga, Anamaria, Bell, Christopher F, DuCharme, Mary, Trenz, Helen, Singer, David, Odedra, Heena |
| المصدر: | Rheumatology ; volume 63, issue Supplement_1 ; ISSN 1462-0324 1462-0332 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | Background/Aims Herpes zoster (HZ) results from reactivation of the varicella-zoster virus and is characterized by a painful dermatomal rash. HZ is associated with increased healthcare costs and reduced patient quality of life. Objectives: To estimate HZ incidence in patients with systemic lupus erythematosus (SLE) and in a general immunocompetent adult population in the United States. Methods This retrospective cohort study used administrative claims data (Optum Research Database) to identify adults (≥18 years) between October 2015 and May 2022 who were assigned to one of two cohorts based on ICD-10-CM diagnosis codes: SLE cohort and immunocompetent cohort. Patients with diagnosis codes for other immunocompromising conditions (ICC) were excluded from the immunocompetent cohort and from the main SLE cohort to create a sub-cohort (SLE without other ICC). The immunocompetent cohort represented a random sample of one million individuals meeting the cohort criteria. Indexing occurred at the later of 12 months of continuous enrollment (CE) or the first SLE diagnosis for the SLE cohorts, and after 12 months of CE for the immunocompetent cohort. Patients with HZ vaccination prior to index or a HZ diagnosis in the 12-month baseline period were excluded. Patients were followed for a variable period from index until the earlier of an incident HZ diagnosis or censoring event (HZ vaccination, disenrollment, death, or the end of the study period). Overall incidence rates of HZ were estimated in each cohort and stratified by age at index, and by baseline disease severity for the SLE cohorts using a published algorithm. Results The SLE cohort included 60,430 patients, among which 21,206 comprised the SLE without other ICC cohort. The immunocompetent cohort included 1,000,000 patients. Mean (standard deviation) age and percent female for the SLE (55 [15] years; 89% female) and for the SLE without other ICC (53 [16] years; 89% female) cohorts were higher compared to the immunocompetent (46 [18] years; 50% female) cohort ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/rheumatology/keae163.090 |
| الاتاحة: | http://dx.doi.org/10.1093/rheumatology/keae163.090 https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.090/57303871/keae163.090.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.9F54102D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keae163.090 |
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