Academic Journal
GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)
| العنوان: | GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae) |
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| المؤلفون: | Mohammad Al-Nuri, Ibrahim M. Abu-Reidah, Anwar A. Alhajeh, Ghadeer Omar, Ghaleb Adwan, Ismail Warad |
| المصدر: | Processes, Vol 10, Iss 1016, p 1016 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Micromeria fruticosa, GC-MS, metabolites, antitumor activity, MTT, antimicrobial activity, Chemical technology, TP1-1185, Chemistry, QD1-999 |
| الوصف: | The present study assessed the metabolites and bioactivities of Micromeria fruticosa plant parts extracted with various solvents (ethanol, n -hexane, and water) through the steeping extraction method. Thereafter, the extracts were analyzed using GC-MS. Moreover, the extracts were tested for their antioxidant, antimicrobial, and antitumor activities. The quali-quantitative analysis of Micromeria fruticosa crude extracts revealed the occurrence of 27 secondary metabolites. Some major bioactives identified were menthone, oleamide, pulegone, and menthol. Numerous antioxidant minerals, viz., Fe, Zn, and Mn, were present. The water extract of leaves exhibited the highest DPPH scavenging activity (89.73%), followed by the water extract of flowers (80.07%) at 100 μg/mL. The stems’ water extract demonstrated greater antimicrobial activity against all the bacteria species tested. The ethanolic leaf and aqueous stem extracts exhibited strong activity against C. albicans and E. coli . Flowers’ aqueous extract demonstrated the highest cytostatic effect on the colon cell line by reducing viability, followed by the leaves’ ethanol extract. The extraction solvents influenced the recovery of phytocompounds, and the highest pharmacological activities of the different extracts could be correlated to the presence of additional bioactives. Our results suggest that the Micromeria fruticosa plant is a favorable source of natural products with promising properties for potential nutraceutical and functional food applications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2227-9717 |
| Relation: | https://www.mdpi.com/2227-9717/10/5/1016; https://doaj.org/toc/2227-9717; https://doaj.org/article/90d0e283186341cfbb5100741e83c56d |
| DOI: | 10.3390/pr10051016 |
| الاتاحة: | https://doi.org/10.3390/pr10051016 https://doaj.org/article/90d0e283186341cfbb5100741e83c56d |
| رقم الانضمام: | edsbas.9F40F341 |
| قاعدة البيانات: | BASE |
| تدمد: | 22279717 |
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| DOI: | 10.3390/pr10051016 |