Academic Journal
A phase I study to evaluate a human papillomavirus (HPV)
| العنوان: | A phase I study to evaluate a human papillomavirus (HPV) |
|---|---|
| المؤلفون: | Kevin A Ault, Anna R Giuliano, Robert P Edwards, Gretchen Tamms, Lee-Lian Kim, Judith F Smith, Kathrin U Jansen, Maria Allende, Frank J Taddeo, Deemarie Skulsky, Eliav Barr |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.hu.ufsc.br/projeto_hpv/A%20phase%20I%20study%20to%20evaluate%20a%20human%20papillomavirus.pdf. |
| سنة النشر: | 2004 |
| المجموعة: | CiteSeerX |
| الوصف: | Human papillomavirus (HPV) infection can cause genital warts and cervical cancer. HPV types 6 and 11 cause >90% of genital wart cases; HPV16 and 18 cause 70% of cervical cancers. A prophylactic HPV (types 6, 11, 16, 18) L1 virus-like particle (VLP) vaccine may substantially reduce the incidence of these lesions. This report describes the results of a phase I study of the HPV18 component of such a vaccine. Forty women were randomized to receive either HPV18 L1 VLP vaccine or placebo. Anti-HPV18 responses were measured using a competitive radioimmunoassay (cRIA). Tolerability was evaluated using vaccination report cards (VRC). The study showed that the HPV18 L1 VLP vaccine was generally well-tolerated and highly immunogenic. Peak anti-HPV18 geometric mean titers (GMT) in vaccines were 60-fold greater than those observed in women following natural HPV18 infection. Further studies of a multivalent HPV L1 VLP vaccines are warranted. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1052.4278; http://www.hu.ufsc.br/projeto_hpv/A%20phase%20I%20study%20to%20evaluate%20a%20human%20papillomavirus.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1052.4278 http://www.hu.ufsc.br/projeto_hpv/A%20phase%20I%20study%20to%20evaluate%20a%20human%20papillomavirus.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.9EE651AF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |