التفاصيل البيبلوغرافية
| العنوان: |
Construction of the Gypsum-Coated Scaffolds for In Situ Bone Regeneration |
| المؤلفون: |
Wenchao He (9312369), Zhen Wu (358187), Yanmei Wu (6438191), Zhou Zhong (1940254), Youliang Hong (1699363) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Cell Biology, Physiology, Biotechnology, Developmental Biology, Cancer, Hematology, Plant Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, bone defects, G-TCP scaffolds, microenvironment, epitaxial gypsum growth method, bone tissue engineering, gypsum-coated β- tricalcium phosphate, bone-like apatite layer, bone-like apatite nanoplates, as-prepared scaffolds, calcium ion concentration, Situ Bone Regeneration, gypsum degradation, bone marrow mesenchymal, vivo experiments, BM-MSC |
| الوصف: |
It is significant to use functional biomaterials to rationally engineer microenvironments for in situ bone regeneration in the field of bone tissue engineering. To this end, we constructed the gypsum-coated β-tricalcium phosphate (G-TCP) scaffolds by combing a three-dimensional printing technique and an epitaxial gypsum growth method. In vitro simulation experiments showed that the as-prepared scaffolds could establish a dynamic and weakly acidic microenvironment in a simulated body liquid, in which the pH and the calcium ion concentration always changed due to the gypsum degradation and growth of bone-like apatite nanoplates on the scaffold surfaces. The cell experiments confirmed that the microenvironment established by the G-TCP surfaces promoted rapid osteogenic differentiation and proliferation of bone marrow mesenchymal stem cells (BM-MSCs). In vivo experiments confirmed that the G-TCP scaffolds had high bioactivity in modulating in situ regeneration of bone, and the bioactivity of the G-TCP scaffolds was endowed by correct pore structures, degradation of gypsum, and growth of a bone-like apatite layer. The microenvironment established by the gypsum degradation could stimulate tissue inflammation and recruit white blood cells and BM-MSCs and thus accelerating native healing cascades of the bone defects via a bone growth/remodeling–absorption cycle process. Furthermore, in vivo experiments demonstrated that after the bone defects had healed completely, the as-prepared scaffolds also degraded completely within 24 weeks. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Construction_of_the_Gypsum-Coated_Scaffolds_for_In_Situ_Bone_Regeneration/14867071 |
| DOI: |
10.1021/acsami.1c08372.s001 |
| الاتاحة: |
https://doi.org/10.1021/acsami.1c08372.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.9EDD4F70 |
| قاعدة البيانات: |
BASE |