Academic Journal
Cognitive and functional changes in prediagnostic phase of Parkinson disease: A population-based study ; : Parkinsonism Relat Disord
| العنوان: | Cognitive and functional changes in prediagnostic phase of Parkinson disease: A population-based study ; : Parkinsonism Relat Disord |
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| المؤلفون: | Foubert-Samier, Alexandra, Helmer, Catherine, Le Goff, Mélanie, Guillet, Florian, Proust-Lima, Cecile, Jacqmin-Gadda, Helene, Dartigues, Jean-François, Amieva, Helene, Tison, F. |
| المساهمون: | Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies Neurodégénératives Bordeaux (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux, Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) |
| المصدر: | ISSN: 1353-8020. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | Cognition, Parkinson's disease, Prodromal phase, Trajectories, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; IntroductionProdromal non-motor symptoms precede, often by decades, motor signs and diagnosis of Parkinson's disease. It is however still uncertain if cognitive changes belong to the spectrum of non-motor prodromal Parkinson's disease. Thanks to the very long-term follow-up of the PAQUID population-based cohort, we assessed trajectories of cognitive complaints and functioning over a 13-year period before the diagnosis of late onset Parkinson's disease.MethodsThis study relies on a matched nested case-control sample selected from the cohort. Of the 3777 initial subjects of the cohort, 43 developed incident Parkinson's disease over the follow-up. The mean age at diagnosis was 78.0 (standard deviation = 5.8) years and 46.5% were men. These cases were matched to 86 elderly control subjects. Scores of different cognitive domains, daily function, and depressive symptoms were described throughout the follow-up using mixed-effects models.ResultsNo significant global cognitive decline preceded the diagnosis of late onset Parkinson's disease. However, psychomotor speed appeared significantly slower 2 years before the diagnosis and depressive symptoms 12 years before. Global score of instrumental activities of daily living became altered 2–3 years preceding the diagnosis of late onset Parkinson's disease, including the use of public transportation that was altered ten years before the diagnosis.ConclusionIn late onset Parkinson's disease, while global cognitive functions seem preserved, psychomotor speed starts to decline 2 years before the diagnosis and activities of daily living are also impacted. Depressive symptoms appear very early in the prediagnosic phase. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32862017; hal-03120461; https://hal.science/hal-03120461; https://hal.science/hal-03120461/document; https://hal.science/hal-03120461/file/S135380202030688X.pdf; PII: S1353-8020(20)30688-X; PUBMED: 32862017 |
| DOI: | 10.1016/j.parkreldis.2020.08.022 |
| الاتاحة: | https://hal.science/hal-03120461 https://hal.science/hal-03120461/document https://hal.science/hal-03120461/file/S135380202030688X.pdf https://doi.org/10.1016/j.parkreldis.2020.08.022 |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.9ED7EE3F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.parkreldis.2020.08.022 |
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