Academic Journal
Rates and ProteinBinding
| العنوان: | Rates and ProteinBinding |
|---|---|
| المؤلفون: | Nh /_c, Interactionof Cisplatinand Carboplatinwithsodiumthiosulfate:reaction, F. Elferink, I. Klein, H. M. Plnedo |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.clinchem.org/content/32/4/641.full.pdf. |
| سنة النشر: | 1985 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | Cisplatin [cis-diamminedichloroplatinum(JJ, Figure 11 is |
| الوصف: | Toxicity of cisplatin can be decreased by concomitant admin-istration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied the disap-pearanceof cisplatinand carboplatinin aqueoussolutionsof thiosulfateat 37#{176}Cby means of liquidchromatography.At initialconcentrationsthat were similarto therapeuticconcen-trationsin plasma, both drugsdisappeared,with half-livesof 66 and 537 mm for cisplatin and carboplatin, respectively. At higher thiosulfate concentrations, as found in urine, the respectivehalf-liveswere 3.7 and 33.8 mm. These values suggestthat direct chemical interaction in the plasma com-partmenthas limited therapeuticconsequences,whereasthe anti-toxiceffectof thiosulfatemightbe explainedbythe rapid inactivationof cisplatinin the kidneys.Reactionproductsof cisplatinand thiosulfatebound instantaneouslyand mainly reversiblyto plasma proteins. Protein-boundcisplatinwas not released by added thiosulfate-which may explainwhy thiosulfate,to be effective,must be given in advance of and during cisplatmnadministration. AddItIonal Keyphrases: pharmacokinetics “J ” chemo-therapy chromatography, reversed-phase cancer |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.500.2377; http://www.clinchem.org/content/32/4/641.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.500.2377 http://www.clinchem.org/content/32/4/641.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.9ECE9334 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |