Academic Journal
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations
| العنوان: | Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations |
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| المؤلفون: | Cornejo-García, José Antonio, Liou, Lieh-Bang, Blanca, Natalia, Doña, Inmaculada, Chen, Chien-Hsiun, Chou, Yi-Chun, Chuang, Hui-Ping, Wu, Jer-Yuarn, Chen, Yuan-Tsong, del Carmen Plaza-Serón, Maria, Mayorga, Cristobalina, Guéant-Rodriguez, Rosa María, Lin, Shih-Chang, Torres, María José, Campo, Paloma, Rondon, Carmen, Laguna, José Julio, Fernández, Javier, Guéant, Jean-Louis, Canto, Gabriela, Blanca, Miguel, Lee, Ming Ta Michael |
| المساهمون: | Allergy Service Carlos Haya Hospital, Hospital Regional Universitario Carlos Haya, Chang Gung Memorial Hospital and University, Allergy Service Hospital Universitario Infanta Leonor, Hospital Universitario Infanta Leonor Madrid, Academia Sinica, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cathay General Hospital Taipei, Allergy Unit Cruz Roja-Madrid, Hospital Central de la Cruz Roja San Jose y Santa Adela, Allergy Section Alicante, Universidad de Alicante, RIKEN Center for Integrative Medical Sciences Yokohama (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research Japon (RIKEN), China Medical University Taichung |
| المصدر: | ISSN: 1462-2416. |
| بيانات النشر: | HAL CCSD Future Medicine |
| سنة النشر: | 2013 |
| المجموعة: | Université de Lorraine: HAL |
| مصطلحات موضوعية: | acute urticaria/angioedema, drug hypersensitivity, genome-wide association study, mast cells NSAIDs, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Aim: Acute urticaria/angioedema (AUA) induced by cross-intolerance to NSAIDs is the most frequent clinical entity in hypersensitivity reactions to drugs. In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA. Materials & methods: A whole-genome scan was performed on a total of 232 cases (112 Spanish and 120 Han Chinese) with NSAID-induced AUA and 225 unrelated controls (124 Spanish and 101 Han Chinese). Results: Although no polymorphism reached genome-wide significance, we obtained suggestive associations for three clusters in the Spanish group (RIMS1, BICC1 and RAD51L 1) and one region in the Han Chinese population (ABI3BP). Five regions showed suggestive associations after meta-analysis: HLF, RAD51L1, COL24A1, GalNAc-T13 and FBXL7. A majority of these genes are related to Ca2+, cAMP and/or P53 signaling pathways. Conclusion: The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-01702843; https://hal.univ-lorraine.fr/hal-01702843 |
| DOI: | 10.2217/pgs.13.166 |
| الاتاحة: | https://hal.univ-lorraine.fr/hal-01702843 https://doi.org/10.2217/pgs.13.166 |
| رقم الانضمام: | edsbas.9EBD5359 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2217/pgs.13.166 |
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