Academic Journal
Failure of a Chloroquine Chemoprophylaxis Program to Adequately Prevent Malaria during Pregnancy in Koupéla District, Burkina Faso
| العنوان: | Failure of a Chloroquine Chemoprophylaxis Program to Adequately Prevent Malaria during Pregnancy in Koupéla District, Burkina Faso |
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| المؤلفون: | Monica E. Parise, Robert D. Newman |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.tulane.edu/~trmd700/jtamba.pdf. |
| سنة النشر: | 2003 |
| المجموعة: | CiteSeerX |
| الوصف: | In West Africa, administration of chloroquine chemoprophylaxis during pregnancy is common, but little is known about its impact on Plasmodium falciparum infection during pregnancy. Therefore, cross-sectional studies in antenatal care clinics (ANCs) and delivery units (DUs) were conducted in Koupéla District, Burkina Faso. Chloroquine chemoprophylaxis was reported by 69 % of 597 pregnant women at ANCs and by 93 % of 853 women in DUs. P. falciparum peripheral parasitemia was identified in 29 % of women at both ANCs and DUs. Placental parasitemia was identified in 22 % of delivering women and was strongly associated with low birth weight (LBW) (risk ratio [RR], 1.7; 95 % confidence interval [CI], 1.2–2.4) and prematurity (RR, 2.9; 95 % CI, 1.6–5.4). In multivariate analysis, use of chemoprophylaxis was not associated with a reduction in the prevalence of placental parasitemia, LBW, or prematurity. Despite the high reported chloroquine che-moprophylaxis coverage, peripheral and placental malaria rates remain high and are associated with known adverse outcomes during pregnancy, including maternal anemia, prematurity, and LBW. Alternative prevention strategies, such as use of insecticide-treated mosquito nets and intermittent preventive treatment with more-effective antimalarials, are needed. Malarial infection during pregnancy poses substantial risk to the mother, her fetus, and the neonate. In areas |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.596.8747; http://www.tulane.edu/~trmd700/jtamba.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.596.8747 http://www.tulane.edu/~trmd700/jtamba.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.9E962E81 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |