Academic Journal
Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
| العنوان: | Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties |
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| المؤلفون: | Kuda, O. (Ondřej), Březinová, M. (Marie), Rombaldová, M. (Martina), Slavíková, B. (Barbora), Pošta, M. (Martin), Beier, P. (Petr), Janovská, P. (Petra), Veleba, J., Kopecký Jr., J., Kudová, E. (Eva), Pelikánová, T., Kopecký, J. (Jan) |
| سنة النشر: | 2016 |
| المجموعة: | The Czech Academy of Sciences: Publication Activity (ASEP) / Akademie věd ČR - Publikační činnost |
| مصطلحات موضوعية: | FAHFA, n-3 PUFA, white adipose tissue, lipokine |
| الوصف: | White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obese individuals, contributes to the development of insulin resistance and type 2 diabetes. n-3 polyunsaturated fatty acids (PUFAs) of marine origin play an important role in the resolution of inflammation and exert beneficial metabolic effects. Using experiments in mice and overweight/obese patients with type 2 diabetes, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids—lipokines derived from docosahexaenoic acid (DHA) and linoleic acid, which were present in serum and WAT after n-3 PUFA supplementation. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) or 14-hydroxydocosahexaenoic acid (HDHA), termed 9-DHAHLA, 13-DHAHLA, and 14-DHAHDHA, and were synthesized by adipocytes at concentrations comparable to those of protectins and resolvins derived from DHA in WAT. 13-DHAHLA exerted anti-inflammatory and proresolving properties while reducing macrophage activation by lipopolysaccharides and enhancing the phagocytosis of zymosan particles. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed to n-3 PUFAs, in both mice and humans. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0012-1797 1939-327x |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/27313314; urn:pissn: 0012-1797; urn:eissn: 1939-327x; http://hdl.handle.net/11104/0261999 |
| DOI: | 10.2337/db16-0385 |
| الاتاحة: | https://doi.org/10.2337/db16-0385 http://hdl.handle.net/11104/0261999 |
| رقم الانضمام: | edsbas.9E844BB7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00121797 1939327x |
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| DOI: | 10.2337/db16-0385 |