Academic Journal
Efficacy of Lansoprazole against Peptic Ulcers Induced by Nonsteroidal Anti-Inflammatory Drugs: Endoscopic Evaluation of Ulcer Healing
| العنوان: | Efficacy of Lansoprazole against Peptic Ulcers Induced by Nonsteroidal Anti-Inflammatory Drugs: Endoscopic Evaluation of Ulcer Healing |
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| المؤلفون: | Matsukawa, Y, Tomita, Y, Nishinarita, S, Horie, T, Kato, K, Arakawa, Y, Ko, K, Shimada, H, Nakano, M, Kitami, Y, Kurosaka, H |
| المصدر: | Journal of International Medical Research ; volume 25, issue 4, page 190-195 ; ISSN 0300-0605 1473-2300 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 1997 |
| الوصف: | Beyond the obvious step of limiting use of non-steroidal anti-inflammatory drugs (NSAIDs), the treatment of ulcers induced by NSAIDs remains controversial. We evaluated the efficacy of the proton-pump inhibitor lansoprazole on NSAID-induced ulcers. Ulcers were endoscopically diagnosed in 47 NSAID users. These patients received 30 mg/day lansoprazole, orally, for 6 or 8 weeks (6 weeks for duodenal ulcers and 8 weeks for other ulcers). Ulcer healing was assessed using an established classification system. The presence of immunoglobulin G antibody against Helicobacter pylori was also evaluated. The antibody was present in the sera of 51% of patients (24/47). Most of the ulcers reached scarring stages S 1 (healing) or S 2 (good healing), and the S 2 healing rate was 35%. Two H. pylori seropositive patients did not reach these stages; their ulcers were improved by H. pylori eradication therapy, followed, in one case, by medication with misoprostol. Lansoprazole seemed to be useful for most patients with NSAID-induced ulcers, but a few needed additional treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/030006059702500403 |
| الاتاحة: | https://doi.org/10.1177/030006059702500403 https://journals.sagepub.com/doi/pdf/10.1177/030006059702500403 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.9E7D7322 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/030006059702500403 |
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