Academic Journal
Guidelines for Diagnosis and Treatment of Chronic Lymphocytic Leukemia. Krohem B-Cll 2017
| العنوان: | Guidelines for Diagnosis and Treatment of Chronic Lymphocytic Leukemia. Krohem B-Cll 2017 |
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| المؤلفون: | Branimir Jakšić, Vlatko Pejša, Slobodanka Ostojić-Kolonić, Ika Kardum-Skelin, Sandra Bašić-Kinda, Božena Coha, Velka Gverić-Krečak, Radovan Vrhovac, Ozren Jakšić, Igor Aurer, Jasminka Sinčić-Petričević, Antica Načinović-Duletić, Damir Nemet |
| المصدر: | Acta Clinica Croatica, Vol 57., Iss 1., Pp 190-215 (2018) |
| بيانات النشر: | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Chronic lymphocytic leukemia, Practice guidelines as topic, Precision medicine, Croatia, KROHEM, Medicine |
| الوصف: | Recent developments in the diagnosis and treatment of chronic lymphocytic leukemia (B-CLL) have led to change of approach in clinical practice. New treatments have been approved based on the results of randomized multicenter trials for first line and for salvage therapy, and the results of numerous ongoing clinical trials are permanently providing new answers and further refining of therapeutic strategies. This is paralleled by substantial increase in understanding the disease genetics due to major advances in the next generation sequencing (NGS) technology. We define current position of the Croatian Cooperative Group for Hematologic Disease on diagnosis and treatment of CLL in the transition from chemo-immunotherapy paradigm into a new one that is based on new diagnostic stratification and unprecedented therapeutic results of B-cell receptor inhibitors (BRI) and Bcl-2 antagonists. This is a rapidly evolving field as a great number of ongoing clinical trials constantly accumulate and provide new knowledge. We believe that novel therapy research including genomic diagnosis is likely to offer new options that will eventually lead to time limited therapies without chemotherapy and more effective clinical care for B-CLL based on individualized precision medicine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0353-9466 1333-9451 |
| Relation: | https://hrcak.srce.hr/file/297715; https://doaj.org/toc/0353-9466; https://doaj.org/toc/1333-9451; https://doaj.org/article/3456c52f7ecf4f5f94305aa0fcdf4b6f |
| DOI: | 10.20471/acc.2018.57.01.27 |
| الاتاحة: | https://doi.org/10.20471/acc.2018.57.01.27 https://doaj.org/article/3456c52f7ecf4f5f94305aa0fcdf4b6f |
| رقم الانضمام: | edsbas.9E6C2D4D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03539466 13339451 |
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| DOI: | 10.20471/acc.2018.57.01.27 |