التفاصيل البيبلوغرافية
| العنوان: |
Substrate spectrum of tyrocidine thioesterase probed with randomized peptide N-acetylcysteamine thioesters |
| المؤلفون: |
Xie, Guiyang, Uttamchandani, Mahesh, Chen, Grace Y.J., Bu, Xianzhang, Lin, San San, Wong, Ka Man, Yan, Weili, Yao, Shao Q., Guo, Zhihong |
| سنة النشر: |
2002 |
| المجموعة: |
The Hong Kong University of Science and Technology: HKUST Institutional Repository |
| مصطلحات موضوعية: |
Acetylcysteine: chemistry, Anti-Infective Agents: chemical synthesis, Anti-Infective Agents: pharmacokinetics, Esterases: metabolism, Kinetics, Oligopeptides: chemical synthesis, Oligopeptides: pharmacokinetics, Substrate Specificity, Sulfhydryl Compounds: chemistry, Tyrocidine: metabolism |
| الوصف: |
Apparent kinetic constants k(cat) and K-m were determined for tyrocidine thioesterase (TycC TE) using randomized peptide N-acetylcysteamine thioesters as substrate analogues. The enzyme has been found to be adequately active for the synthesis of positional-scanning libraries for novel antibiotic screening with reduced k(cat)/K-m in the range of 2 to 82 folds lower than that of the wild-type sequence. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0960-894X |
| Relation: |
https://repository.hkust.edu.hk/ir/Record/1783.1-29726; Bioorganic & medicinal chemistry letters, v. 12, (6), 2002, MAR 25, p. 989-992; https://doi.org/10.1016/S0960-894X(02)00067-7; http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0960-894X&rft.volume=12&rft.issue=6&rft.date=2002&rft.spage=989&rft.epage=992&rft.aulast=Xie&rft.aufirst=GY&rft.atitle=Substrate+spectrum+of+tyrocidine+thioesterase+probed+with+randomized+peptide+N-acetylcysteamine+thioesters; http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000175291700037; http://www.scopus.com/record/display.url?eid=2-s2.0-0037170820&origin=inward |
| DOI: |
10.1016/S0960-894X(02)00067-7 |
| الاتاحة: |
https://repository.hkust.edu.hk/ir/Record/1783.1-29726
https://doi.org/10.1016/S0960-894X(02)00067-7
http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0960-894X&rft.volume=12&rft.issue=6&rft.date=2002&rft.spage=989&rft.epage=992&rft.aulast=Xie&rft.aufirst=GY&rft.atitle=Substrate+spectrum+of+tyrocidine+thioesterase+probed+with+randomized+peptide+N-acetylcysteamine+thioesters
http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000175291700037
http://www.scopus.com/record/display.url?eid=2-s2.0-0037170820&origin=inward |
| رقم الانضمام: |
edsbas.9E6738A2 |
| قاعدة البيانات: |
BASE |