Academic Journal
Self-Healing Injectable Polymer Hydrogel via Dynamic Thiol-Alkynone Double Addition Cross-Links
| العنوان: | Self-Healing Injectable Polymer Hydrogel via Dynamic Thiol-Alkynone Double Addition Cross-Links |
|---|---|
| المؤلفون: | Fan, B. (author), Zhang, K. (author), Liu, Q. (author), Eelkema, R. (author) |
| سنة النشر: | 2020 |
| المجموعة: | Delft University of Technology: Institutional Repository |
| الوصف: | Introduction of dynamic thiol-alkynone double addition cross-links in a polymer network enable the formation of a self-healing injectable polymer hydrogel. A four-arm polyethylene glycol (PEG) tetra-thiol star polymer is cross-linked by a small molecule alkynone via the thiol-alkynone double adduct to generate a hydrogel network under ambient aqueous conditions (buffer pH = 7.4 or 8.2, room temperature). The mechanical properties of these hydrogels can be easily tuned by varying the concentration of polymer precursors. Through the dynamic thiol-alkynone double addition cross-link, these hydrogels are self-healing and shear thinning, as demonstrated by rheological measurements, macroscopic self-healing, and injection tests. These hydrogels can be injected through a 20G syringe needle and recover after extrusion. In addition, good cytocompatibility of these hydrogels is confirmed by cytotoxicity test. This work shows the application of the thiol-alkynone double addition dynamic covalent chemistry in the straightforward preparation of self-healing injectable hydrogels, which may find future biomedical applications such as tissue engineering and drug delivery. ; ChemE/Advanced Soft Matter ; ChemE/Product and Process Engineering |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://www.scopus.com/inward/record.url?scp=85085886088&partnerID=8YFLogxK; ACS Macro Letters--47637bd5-e6a9-4a1e-b312-388c0c1507d1; http://resolver.tudelft.nl/uuid:61ba737d-bfbc-4c05-bde5-f33222c01f79; https://doi.org/10.1021/acsmacrolett.0c00241 |
| DOI: | 10.1021/acsmacrolett.0c00241 |
| الاتاحة: | http://resolver.tudelft.nl/uuid:61ba737d-bfbc-4c05-bde5-f33222c01f79 https://doi.org/10.1021/acsmacrolett.0c00241 |
| Rights: | © 2020 B. Fan, K. Zhang, Q. Liu, R. Eelkema |
| رقم الانضمام: | edsbas.9E658BDA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsmacrolett.0c00241 |
|---|