Academic Journal
Infant gut microbiota contributes to cognitive performance in mice
| العنوان: | Infant gut microbiota contributes to cognitive performance in mice |
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| المؤلفون: | Cerdó, Tomás, Ruiz Rodríguez, Alicia, Acuña Morales, Inmaculada, Torres Espínola, Francisco José, Menchén Márquez, Sergio, Gámiz Ruiz, Fernando, Gallo Torre, Milagros, Jehmlich, Nico, Haange, Sven-Bastiaan, Von Bergen, Martin, Campoy Folgoso, Cristina, Suárez García, Antonio Francisco |
| سنة النشر: | 2023 |
| المجموعة: | DIGIBUG: Repositorio Institucional de la Universidad de Granada |
| مصطلحات موضوعية: | Cognition, Germ-free mice, Gut, Histidine metabolome, Infant, Microbiota, Metaproteomics |
| الوصف: | Work in the author’s laboratories was performed on resources provided by the Spanish Health and Science Ministries (PREOBE project P06-CTS-02341, BFU2012-40254-C03-01, and PID2020-114269GB-I00), Junta de Andalucía, and UFZ-Germany. T.C. participated in the PhD program in biomedicine at UGR, was a fellowship of the FPI program (BES-2013-065133) funded by the Spanish Ministry of Economy and Competitiveness, and is currently supported by the ‘‘Sara Borrell’’ program (CD21/00187) of the Carlos III Institute. I.A., S.M.-M., and A.R.-R. were granted PhD scholarships (FPU) from the Spanish Ministry of Economy and Competitiveness. A.R.-R. currently holds a María Zambrano Next Generation EU-Talent Reincorporation from UGR. ; Gut microbiota has been related to infant neurodevelopment. Here, an association between infant composite cognition with gut microbiota composition was established as soon as 6 months. Higher diversity and evenness characterized microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses established an association between microbial histidine ammonia lyase activity and infant histidine metabolome with cognition. Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice showed that memory, assessed by novel object recognition test, was a transmissible trait. Furthermore, Inf-aboveCC mice were enriched in species previously linked to cognition belonging to Bacteroides, Phaeicola and Bifidobacterium. Finally, Inf-aboveCC mice showed differential faecal histidine, hippocampal urocanate and histidine-urocanate-glutamate ratios compared to Inf-aboveCC mice. Overall, these findings reveal a causative role of gut microbiota on infant cognition pointing at modulation of histidine metabolite levels as a potential underlying mechanism. ; Spanish Health and Science Ministries (PREOBE project P06-CTS-02341, BFU2012-40254-C03-01, PID2020-114269GB-I00) ; Junta de Andalucía ; UFZ-Germany ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Published version: Cerdó, Tomás et al. Infant gut microbiota contributes to cognitive performance in mice. Cell Host Microbe. 2023. Dec 13;31(12):1974-1988.e4. [doi:10.1016/j.chom.2023.11.004]; https://hdl.handle.net/10481/86758 |
| DOI: | 10.1016/j.chom.2023.11.004 |
| الاتاحة: | https://hdl.handle.net/10481/86758 https://doi.org/10.1016/j.chom.2023.11.004 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9E3BB9CB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.chom.2023.11.004 |
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