Academic Journal
Post‐exercise intramuscular O 2 supply is tightly coupled with a higher proximal‐to‐distal ATP synthesis rate in human tibialis anterior
| العنوان: | Post‐exercise intramuscular O 2 supply is tightly coupled with a higher proximal‐to‐distal ATP synthesis rate in human tibialis anterior |
|---|---|
| المؤلفون: | Heskamp, Linda, Lebbink, Franciska, van Uden, Mark J., Maas, Marnix C., Claassen, Jurgen A. H. R., Froeling, Martijn, Kemp, Graham J., Boss, Andreas, Heerschap, Arend |
| المصدر: | The Journal of Physiology ; volume 599, issue 5, page 1533-1550 ; ISSN 0022-3751 1469-7793 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Key points The post‐exercise recovery of phosphocreatine, a measure of the oxidative capacity of muscles, as assessed by 31 P MR spectroscopy, shows a striking increase from distal to proximal along the human tibialis anterior muscle. To investigate why this muscle exhibits a greater oxidative capacity proximally, we tested whether the spatial variation in phosphocreatine recovery rate is related to oxygen supply, muscle fibre type or type of exercise. We revealed that oxygen supply also increases from distal to proximal along the tibialis anterior, and that it strongly correlated with phosphocreatine recovery. Carnosine level, a surrogate measure for muscle fibre type was not different between proximal and distal, and type of exercise did not affect the gradient in phosphocreatine recovery rate. Taken together, the findings of this study suggest that the post‐exercise spatial gradients in oxygen supply and phosphocreatine recovery are driven by a higher intrinsic mitochondrial oxidative capacity proximally. Abstract Phosphorus magnetic resonance spectroscopy ( 31 P MRS) of human tibialis anterior (TA) revealed a strong proximo‐distal gradient in the post‐exercise phosphocreatine (PCr) recovery rate constant ( k PCr ), a measure of muscle oxidative capacity. The aim of this study was to investigate whether this k PCr gradient is related to O 2 supply, resting phosphorylation potential, muscle fibre type, or type of exercise. Fifteen male volunteers performed continuous isometric ankle dorsiflexion at 30% maximum force until exhaustion. At multiple locations along the TA, we measured the oxidative PCr resynthesis rate ( V PCr = k PCr × PCr depletion) by 31 P MRS, the oxyhaemoglobin recovery rate constant ( k O2Hb ) by near infrared spectroscopy, and muscle perfusion with MR intravoxel incoherent motion imaging. The k O2Hb , k PCr , V PCr and muscle perfusion depended on measurement location ( P < 0.001, P < 0.001, P = 0.032 and P = 0.003, respectively), all being greater proximally. The k O2Hb and muscle ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1113/jp280771 |
| DOI: | 10.1113/JP280771 |
| الاتاحة: | http://dx.doi.org/10.1113/jp280771 https://onlinelibrary.wiley.com/doi/pdf/10.1113/JP280771 https://onlinelibrary.wiley.com/doi/full-xml/10.1113/JP280771 https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/JP280771 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.9E3446A9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1113/jp280771 |
|---|