Academic Journal
Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance
| العنوان: | Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance |
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| المؤلفون: | Bao, Jiahao, Zhao, Zhiyang, Qin, Shanmei, Cheng, Mengjia, Wang, Yiming, Li, Meng, Jia, Pingping, Li, Jinhui, Yu, Hongbo |
| المساهمون: | National Natural Science Foundation of China, Multi-center clinical research project of Shanghai Jiao Tong University School of Medicine |
| المصدر: | BMC Psychiatry ; volume 24, issue 1 ; ISSN 1471-244X |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Background Obstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and cognitive impairments. However, the causal association of OSA with brain morphology and cognitive performance has not been determined. Methods We conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between OSA and a range of neurocognitive characteristics, including brain cortical structure, brain subcortical structure, brain structural change across the lifespan, and cognitive performance. Summary-level GWAS data for OSA from the FinnGen consortium was used to identify genetically predicted OSA. Data regarding neurocognitive characteristics were obtained from published meta-analysis studies. Linkage disequilibrium score regression analysis was employed to reveal genetic correlations between OSA and related traits. Results Our MR study provided evidence that OSA was found to significantly increase the volume of the hippocampus (IVW β (95% CI) = 158.997 (76.768 to 241.227), P = 1.51e-04), with no heterogeneity and pleiotropy detected. Nominally causal effects of OSA on brain structures, such as the thickness of the temporal pole with or without global weighted, amygdala structure change, and cerebellum white matter change covering lifespan, were observed. Bidirectional causal links were also detected between brain cortical structure, brain subcortical, cognitive performance, and OSA risk. LDSC regression analysis showed no significant correlation between OSA and hippocampus volume. Conclusions Overall, we observed a positive association between genetically predicted OSA and hippocampus volume. These findings may provide new insights into the bidirectional links between OSA and neurocognitive features, including brain morphology and cognitive performance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12888-024-05789-x |
| DOI: | 10.1186/s12888-024-05789-x.pdf |
| DOI: | 10.1186/s12888-024-05789-x/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12888-024-05789-x https://link.springer.com/content/pdf/10.1186/s12888-024-05789-x.pdf https://link.springer.com/article/10.1186/s12888-024-05789-x/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.9E264D64 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12888-024-05789-x |
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