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Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease

التفاصيل البيبلوغرافية
العنوان: Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease
المؤلفون: Santos García, Diego, Laguna, A., Hernández-Vara, J., de Deus Fonticoba, T., Cores Bartolomé, Carlos, Feal Painceiras, M.J., Ãñiguez-Alvarado, M.C., García Díaz, I., Jesús, S., Boungiorno, M.T., Planellas, L., Cosgaya, Marina, García Caldentey, J., Caballol, N., Legarda, I., Cabo-Lopez, Iria, López Manzanares, L., González Aramburu, I., Ãvila Rivera, M.A., Gómez Mayordomo, Víctor, Nogueira, V., Puente, Víctor, Dotor García-Soto, J., Borrué, C., Solano Vila, B., Ãlvarez Sauco, M., Vela, L., Escalante, S., Cubo, Esther, Carrillo Padilla, F., Martínez-Castrillo, Juan Carlos, Sánchez Alonso, Pilar, Alonso Losada, M.G., López Ariztegui, Nuria, Gastón, I., Kulisevsky, Jaime, Mendez-Gonzalez, Manuel, Seijo, M., Rúiz Martínez, J., Valero, C., Kurtis, M., Ardura, J.G., Alonso Redondo, R., Ordás, C., López Díaz, L.M., McAfee, D., Martinez-Martin, Pablo, Mir, P., Universitat Autònoma de Barcelona
سنة النشر: 2023
المجموعة: Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB
مصطلحات موضوعية: Gender, Motor, Non-motor symptoms, Parkinson's disease, Quality of life, Sex
الوصف: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 20770383
Relation: Ministerio de Economía y Competitividad PI16/01575; Journal of clinical medicine; Vol. 12 Núm. 4 (february 2023), p. 1329; https://ddd.uab.cat/record/302820; urn:10.3390/jcm12041329; urn:oai:ddd.uab.cat:302820; urn:scopus_id:85149134153; urn:articleid:20770383v12n4p1329; urn:pmid:36835866; urn:pmcid:PMC9960095; urn:oai:pubmedcentral.nih.gov:9960095
الاتاحة: https://ddd.uab.cat/record/302820
Rights: open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.9DC4F1ED
قاعدة البيانات: BASE
الوصف
تدمد:20770383