Academic Journal
Direct comparative study of the effectiveness of mepolizumab and dupilumab in patients with severe non-allergic eosinophilic asthma ; Прямое сравнительное исследование эффективности меполизумаба и дупилумаба у пациентов с тяжелой неаллергической эозинофильной бронхиальной астмой
| العنوان: | Direct comparative study of the effectiveness of mepolizumab and dupilumab in patients with severe non-allergic eosinophilic asthma ; Прямое сравнительное исследование эффективности меполизумаба и дупилумаба у пациентов с тяжелой неаллергической эозинофильной бронхиальной астмой |
|---|---|
| المؤلفون: | V. V. Naumova, E. K. Beltyukov, O. P. Kovtun, G. A. Bykova, O. G. Smolenskaya, A. A. Shtanova, D. A. Stepina, В. В. Наумова, Е. К. Бельтюков, О. П. Ковтун, Г. А. Быкова, О. Г. Смоленская, А. А. Штанова, Д. А. Степина |
| المصدر: | Meditsinskiy sovet = Medical Council; № 20 (2023); 18-27 ; Медицинский Совет; № 20 (2023); 18-27 ; 2658-5790 ; 2079-701X |
| بيانات النشر: | REMEDIUM GROUP Ltd. |
| سنة النشر: | 2023 |
| المجموعة: | Medical Council (E-Journal) / Медицинский Совет |
| مصطلحات موضوعية: | ремиссия тяжелой бронхиальной астмы, targeted therapy, biologics, remission of severe bronchial asthma, таргетная терапия, генно-инженерные биологические препараты |
| الوصف: | Introduction. Biologics for severe asthma (SA) treatment are widely used in real clinical practice. But there are very few direct comparative studies at the moment.Aim. To compare mepolizumab and dupilumab effectiveness in patients with non-allergic eosinophilic SA in real clinical practice using regional register of Sverdlovsk region.Materials and methods. The data of patients with non-allergic eosinophilic SA treated with dupilumab (n = 23) and mepolizumab (n = 19) were analyzed. Therapy effectiveness was determined according to BARS and patients’ proportion who achieved asthma remission, dynamics of ACT, AQLQ, FEV1, blood eosinophils, frequency of short-acting bronchodilators use and systemic glucocorticosteroids (SGCS) demand, frequency of asthma exacerbations and hospitalizations.Results. Within 12 months of targeted therapy a good response to biologics according to BARS in 77.8% of patients on dupilumab and in 82.4% of patients on mepolizumab (p = 1.000) was revealed. Remission of SA (without FEV1) was achieved in 62.5% of patients in dupilumab group and in 68.8% of patients in mepolizumab group (p = 1.000). Remission of SA (with FEV1) was achieved in 43.8% of patients on dupilumab and in 56.2% of patients on mepolizumab (p = 0.724). There were statistically significant improvements for all separately analyzed indicators in each observation group. Statistically significant differences after a year of therapy between groups were recorded in terms of eosinophil levels (p < 0.001) and nasal symptoms assessed using the SNOT-22 questionnaire (p = 0.048) in favour of mepolizumab.Conclusions. Patients with non-allergic eosinophilic SA have good response to both dupilumab and mepolizumab. The drugs equally improve disease control, life quality, reduce the need for relievers and SGCS, show a similar safety level. ; Введение. Генно-инженерные биологические препараты (ГИБП) для лечения тяжелой бронхиальной астмы (ТБА) достаточно широко используются в реальной клинической практике. Но прямых сравнительных ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
| Relation: | https://www.med-sovet.pro/jour/article/view/7881/6996; Chung KF. Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma. Expert Opin Pharmacother. 2004;5(2):439–446. https://doi.org/10.1517/14656566.5.2.439.; Viswanathan RK, Busse WW. How to compare the efficacy of biologic agents in asthma. Ann Allergy, Asthma Immunol. 2020;125(2):137–149. https://doi.org/10.1016/j.anai.2020.04.031.; Doroudchi A, Pathria M, Modena BD. Asthma biologics: Comparing trial designs, patient cohorts and study results. Ann Allergy Asthma Immunol. 2020;124(1):44–56. https://doi.org/10.1016/J.ANAI.2019.10.016.; Castro M, Corren J, Pavord ID, Maspero J, Wenzel S, Rabe KF et al. Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma. N Engl J Med. 2018;378(26):2486–2496. https://doi.org/10.1056/NEJMOA1804092.; Castro M, Zangrilli J, Wechsler ME, Bateman ED, Brusselle GG, Bardin P et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med. 2015;3(5):355–366. https://doi.org/10.1016/S2213-2600(15)00042-9.; FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M et al. Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2128–2141. https://doi.org/10.1016/S0140-6736(16)31322-8.; Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON et al. Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–659. https://doi.org/10.1016/S0140-6736(12)60988-X.; Cabon Y, Molinari N, Marin G, Vachier I, Gamez AS, Chanez P et al. Comparison of anti-interleukin-5 therapies in patients with severe asthma: global and indirect meta-analyses of randomized placebo-controlled trials. Clin Exp Allergy. 2017;47(1):129–138. https://doi.org/10.1111/CEA.12853.; Edris A, De Feyter S, Maes T, Joos G, Lahousse L. Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis. Respir Res. 2019;20(1):179. https://doi.org/10.1186/S12931-019-1138-3.; Henriksen DP, Bodtger U, Sidenius K, Maltbaek N, Pedersen L, Madsen H et al. Efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab anti-IL-5 treatments of severe asthma - a systematic review and meta-analysis. Eur Clin Respir J. 2018;5(1):1536097. https://doi.org/10.1080/20018525.2018.1536097.; Ramonell RP, Iftikhar IH. Effect of Anti-IL5, Anti-IL5R, Anti-IL13 Therapy on Asthma Exacerbations: A Network Meta-analysis. Lung. 2020;198(1):95–103. https://doi.org/10.1007/S00408-019-00310-8.; Busse W, Chupp G, Nagase H, Albers FC, Doyle S, Shen Q et al. Anti-IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison. J Allergy Clin Immunol. 2019;143(1):190–200. https://doi.org/10.1016/J.JACI.2018.08.031.; He LL, Zhang L, Jiang L, Xu F, Fei DS. Efficacy and safety of anti-interleukin-5 therapy in patients with asthma: A pairwise and Bayesian network meta-analysis. Int Immunopharmacol. 2018;64:223–231. https://doi.org/10.1016/J.INTIMP.2018.08.031.; Calzetta L, Matera MG, Rogliani P. Monoclonal antibodies in severe asthma: is it worth it? Expert Opin Drug Metab Toxicol. 2019;15(6):517–520. https://doi.org/10.1080/17425255.2019.1621837.; Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. https://doi.org/10.1183/09031936.00202013.; Milger K, Korn S, Feder C, Fuge J, Mühle A, Schütte W et al. Criteria for evaluation of response to biologics in severe asthma – the Biologics Asthma Response Score (BARS). Pneumologie. 2023;77(4):220–232. https://doi.org/10.1055/A-2014-4350.; Menzies-Gow A, Bafadhel M, Busse WW, Casale TB, Kocks JWH, Pavord ID et al. An expert consensus framework for asthma remission as a treatment goal. J Allergy Clin Immunol. 2020;145(3):757–765. https://doi.org/10.1016/J.JACI.2019.12.006.; Milger K, Suhling H, Skowasch D, Holtdirk A, Kneidinger N, Behr J et al. Response to Biologics and Clinical Remission in the Adult German Asthma Net Severe Asthma Registry Cohort. J Allergy Clin Immunol Pract. 2023;11(9):2701–2712. https://doi.org/10.1016/J.JAIP.2023.05.047.; Ненашева НА. Тяжелая эозинофильная бронхиальная астма: новые возможности терапии. Медицинский cовет. 2018;(15):44–52. https://doi.org/10.21518/2079-701X-2018-15-44-52.; Курбачева ОМ, Дынева МЕ, Ильина НИ. Дупилумаб: основные аспекты применения при T2-опосредованных заболеваниях. Медицинский cовет. 2021;(16):186–196. https://doi.org/10.21518/2079-701X-2021-16-186-196.; Harvey ES, Langton D, Katelaris C, Stevens S, Farah CS, Gillman A et al. Mepolizumab effectiveness and identification of super-responders in severe asthma. Eur Respir J. 2020;55(5)1902420. https://doi.org/10.1183/13993003.02420-2019.; Numata T, Nakayama K, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M et al. Efficacy of mepolizumab for patients with severe asthma and eosinophilic chronic rhinosinusitis. BMC Pulm Med. 2019;19(1):1–9. https://doi.org/10.1186/S12890-019-0952-1.; Iftikhar IH, Schimmel M, Bender W, Swenson C, Amrol D. Comparative Efficacy of Anti IL-4, IL-5 and IL-13 Drugs for Treatment of Eosinophilic Asthma: A Network Meta-analysis. Lung. 2018;196(5):517–530. https://doi.org/10.1007/S00408-018-0151-5.; Akenroye A, Lassiter G, Jackson JW, Keet C, Segal J, Alexander GC et al. Comparative efficacy of mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis. J Allergy Clin Immunol. 2022;150(5):1097–1105. https://doi.org/10.1016/J.JACI.2022.05.024.; Pham DD, Lee JH, Kwon HS, Song WJ, Cho YS, Kim H et al. Prospective direct comparison of biological treatments on severe eosinophilic asthma: Findings from the PRISM study. Ann Allergy Asthma Immunol. 2023;1081–1206. https://doi.org/10.1016/j.anai.2023.05.029.; Tan L, Reibman J, Ambrose C, Chung Y, Desai P, Llanos JP et al. Clinical and economic burden of uncontrolled severe noneosinophilic asthma. Am J Manag Care. 2022;28(6):e212–e220. https://doi.org/10.37765/AJMC.2022.89159.; Kimura Y, Suzukawa M, Inoue N, Imai S, Akazawa M, Matsui H. Real-world benefits of biologics for asthma: Exacerbation events and systemic corticosteroid use. World Allergy Organ J. 2021;14(11):100600. https://doi.org/10.1016/J.WAOJOU.2021.100600.; Agache I, Beltran J, Akdis C, Akdis M, Canelo-Aybar C, Canonica GW et al. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines – recommendations on the use of biologicals in severe asthma. Allergy. 2020;75(5):1023–1042. https://doi.org/10.1111/ALL.14221.; Charles D, Shanley J, Temple SN, Rattu A, Khaleva E, Roberts G. Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: A systematic review and meta-analysis. Clin Exp Allergy. 2022;52(5):616–627. https://doi.org/10.1111/CEA.14112.; Mareque M, Climente M, Martinez-Moragon E, Padilla A, Oyagüez I, Touron C et al. Cost-effectiveness of benralizumab versus mepolizumab and dupilumab in patients with severe uncontrolled eosinophilic asthma in Spain. J Asthma. 2023;60(6):1210–1220. https://doi.org/10.1080/02770903.2022.2139718.; Menzies-Gow A, Steenkamp J, Singh S, Erhardt W, Rowell J, Rane P et al. Tezepelumab compared with other biologics for the treatment of severe asthma: a systematic review and indirect treatment comparison. J Med Econ. 2022;25(1):679–690. https://doi.org/10.1080/13696998.2022.2074195.; Faverio P, Ronco R, Monzio Compagnoni M, Franchi M, Franco G, Bonaiti G et al. Effectiveness and economic impact of Dupilumab in asthma: a populationbased cohort study. Respir Res. 2023;24(1):70. https://doi.org/10.1186/S12931-023-02372-y.; Bleecker E, Blaiss M, Jacob-Nara J, Huynh L, Stanford R, Wang Z et al. Realworld effectiveness of dupilumab and other biologics on asthma exacerbations and steroid prescriptions: US-advantage study. Ann Allergy Asthma Immunol. 2022;129(5):S38. https://doi.org/10.1016/j.anai.2022.08.611.; Pelaia C, Lombardo N, Busceti MT, Piazzetta G, Crimi C, Calabrese C et al. Short-Term Evaluation of Dupilumab Effects in Patients with Severe Asthma and Nasal Polyposis. J Asthma Allergy. 2021;(14):1165–1172. https://doi.org/10.2147/JAA.S328988.; Eldaabossi SAM, Awad A, Anshasi N. Mepolizumab and dupilumab as a replacement to systemic glucocorticoids for the treatment of Chronic Eosinophilic Pneumonia and Allergic Bronchopulmonary Aspergillosis – Case series, Almoosa specialist hospital. Respir Med Case Rep. 2021;34:101520. https://doi.org/10.1016/J.RMCR.2021.101520.; Oda N, Miyahara N, Senoo S, Itano J, Taniguchi A, Morichika D et al. Severe asthma concomitant with allergic bronchopulmonary aspergillosis successfully treated with mepolizumab. Allergol Int. 2018;67(4):521–523. https://doi.org/10.1016/J.ALIT.2018.03.004.; Mümmler C, Kemmerich B, Behr J, Kneidinger N, Milger K. Differential response to biologics in a patient with severe asthma and ABPA: a role for dupilumab? Allergy Asthma Clin Immunol. 2020;16:55. https://doi.org/10.1186/S13223-020-00454-W.; Bateman ED, Khan AH, Xu Y, Guyot P, Chao J, Kamat S et al. Pairwise indirect treatment comparison of dupilumab versus other biologics in patients with uncontrolled persistent asthma. Respir Med. 2022;191:105991. https://doi.org/10.1016/J.RMED.2020.105991.; Nopsopon T, Lassiter G, Chen ML, Alexander GC, Keet C, Hong H et al. Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis. J Allergy Clin Immunol. 2023;151(3):747–755. https://doi.org/10.1016/J.JACI.2022.11.021.; Toma S, Hopkins C. Stratification of SNOT-22 scores into mild, moderate or severe and relationship with other subjective instruments. Rhinology. 2016;54(2):129–133. https://doi.org/10.4193/RHINO15.072.; Chong LY, Piromchai P, Sharp S, Snidvongs K, Webster KE, Philpott C et al. Biologics for chronic rhinosinusitis. Cochrane Database Syst Rev. 2021;3(3):CD013513. https://doi.org/10.1002/14651858.CD013513.PUB3.; Wu Q, Zhang Y, Kong W, Wang X, Yuan L, Zheng R et al. Which Is the Best Biologic for Nasal Polyps: Dupilumab, Omalizumab, or Mepolizumab? A Network Meta-Analysis. Int Arch Allergy Immunol. 2022;183(3):279–288. https://doi.org/10.1159/000519228.; Cai S, Xu S, Lou H, Zhang L. Comparison of Different Biologics for Treating Chronic Rhinosinusitis With Nasal Polyps: A Network Analysis. J Allergy Clin Immunol Pract. 2022;10(7):1876–1886. https://doi.org/10.1016/J.JAIP.2022.02.034.; Oykhman P, Paramo FA, Bousquet J, Kennedy DW, Brignardello-Petersen R, Chu DK. Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis. J Allergy Clin Immunol. 2022;149(4):1286–1295. https://doi.org/10.1016/J.JACI.2021.09.009.; Mümmler C, Dünzelmann K, Kneidinger N, Barnikel M, Munker D, Gröger M et al. Real-life effectiveness of biological therapies on symptoms in severe asthma with comorbid CRSwNP. Clin Transl Allergy. 2021;11(5):e12049. https://doi.org/10.1002/CLT2.12049.; https://www.med-sovet.pro/jour/article/view/7881 |
| DOI: | 10.21518/ms2023-308 |
| الاتاحة: | https://www.med-sovet.pro/jour/article/view/7881 https://doi.org/10.21518/ms2023-308 |
| Rights: | Authors publishing their articles in this journal shall agree to the following:Authors reserve the copyright to the work and grant the journal a license to publish the work for the first time Creative Commons Attribution License (CC BY- NC-ND), which allows other persons to distribute this work with the obligatory preservation of references to the authors of the original work and the original publication in this journal.Authors reserve the right to conclude separate contractual arrangements regarding the non-exclusive distribution of the work version in the form published here (for example, posting it in the institute’s repository, publication in a book), with reference to its original publication in this journal.Authors have the right to post work on the Internet (for example, in the institute’s repository or personal website) before and during the process of considering it by this journal, as this can result in a productive discussion and more references to this work. ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License (CC BY- NC-ND), которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию.Авторы имеют право размещать работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу. (См. The Effect of Open Access). |
| رقم الانضمام: | edsbas.9DA86730 |
| قاعدة البيانات: | BASE |
| DOI: | 10.21518/ms2023-308 |
|---|