Academic Journal
Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
| العنوان: | Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride |
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| المؤلفون: | Osaki, Tomohiro, Gonda, Kengo, Murahata, Yusuke, Sunden, Yuji, Amaha, Takao, Kunisue, Narumi, Takahashi, Kiwamu, Ishizuka, Masahiro, Tanaka, Tohru, Li, Liming, Yokoe, Inoru, Yamashita, Masamichi, Azuma, Kazuo, Tsuka, Takeshi, Ito, Norihiko, Imagawa, Tomohiro, Okamoto, Yoshiharu |
| المساهمون: | This study was partly funded by SBI Pharmaceuticals Co., Ltd., Tokyo, Japan. |
| المصدر: | Journal of Feline Medicine and Surgery Open Reports ; volume 6, issue 1 ; ISSN 2055-1169 2055-1169 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2020 |
| الوصف: | Case summary The present study describes the case of a feline meningioma that was detected using 5-aminolaevulinic acid hydrochloride (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence at surgery. An extra-axial mass in the temporoparietal region was observed by MRI. Following craniectomy and durotomy, photodynamic detection (PDD) was performed for detection of the tumour. Intratumour PpIX was detected using fluorescence spectrum evaluation and high-performance liquid chromatography. PDD revealed bright fluorescence of PpIX induced by 5-ALA, facilitating fluorescence-guided resection of the tumour tissue. Postoperative examination demonstrated an intratumour PpIX protein concentration of 16.8 nmol/g, and based on histopathological findings we diagnosed the mass as meningioma. Relevance and novel information PDD using 5-ALA has been used to identify the surgical margins during resection of primary human brain tumours. Recently, we have reported post-mortem PDD using 5-ALA for a canine glioblastoma. To our knowledge, this technique has not been previously used for the detection and resection of feline brain tumours. Our findings suggest that PDD using 5-ALA is useful for intraoperative fluorescence-guided resection of malignant meningioma in cats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/2055116920907429 |
| الاتاحة: | https://doi.org/10.1177/2055116920907429 https://journals.sagepub.com/doi/pdf/10.1177/2055116920907429 https://journals.sagepub.com/doi/full-xml/10.1177/2055116920907429 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.9D34310A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/2055116920907429 |
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