التفاصيل البيبلوغرافية
| العنوان: |
Building Up a Piperazine Ring from a Primary Amino Group via Catalytic Reductive Cyclization of Dioximes |
| المؤلفون: |
Evgeny V. Pospelov, Alexey Yu. Sukhorukov |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 14; Pages: 11794 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
piperazines, reductive cyclization, Michael addition, oximes, heterogeneous catalytic hydrogenation |
| جغرافية الموضوع: |
agris |
| الوصف: |
Piperazine is one of the most frequently found scaffolds in small-molecule FDA-approved drugs. In this study, a general approach to the synthesis of piperazines bearing substituents at carbon and nitrogen atoms utilizing primary amines and nitrosoalkenes as synthons was developed. The method relies on sequential double Michael addition of nitrosoalkenes to amines to give bis(oximinoalkyl)amines, followed by stereoselective catalytic reductive cyclization of the oxime groups. The method that we developed allows a straightforward structural modification of bioactive molecules (e.g., α-amino acids) by the conversion of a primary amino group into a piperazine ring. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Pharmacology; https://dx.doi.org/10.3390/ijms241411794 |
| DOI: |
10.3390/ijms241411794 |
| الاتاحة: |
https://doi.org/10.3390/ijms241411794 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.9D26408E |
| قاعدة البيانات: |
BASE |