Academic Journal
Effect of food on the antiviral activity of didanosine enteric‐coated capsules: a pilot comparative study *
| العنوان: | Effect of food on the antiviral activity of didanosine enteric‐coated capsules: a pilot comparative study * |
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| المؤلفون: | Hernández‐Novoa, B, Antela, A, Gutiérrez, C, Pérez‐Molina, JA, Pérez‐Elías, MJ, Dronda, F, Moreno, A, Casado, JL, Page, C, Pumares, M, Galán, JC, Moreno, S |
| المصدر: | HIV Medicine ; volume 9, issue 4, page 187-191 ; ISSN 1464-2662 1468-1293 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2008 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objectives To determine the effect of food on the antiviral activity of enteric‐coated (EC) capsules of didanosine (ddI). Methods We conducted a pilot, randomized, open‐label study of 28‐day ddI‐EC capsules monotherapy‐administered in a fasted state (group 1, n =11) or with food (group 2, n =10) to treatment‐naïve chronically HIV‐1‐infected individuals. To assess the antiviral efficacy, HIV‐1 RNA was determined at baseline, day 3, day 7 and weekly thereafter. The area under the HIV‐1 RNA curve minus baseline weighted by time (AUCMB/day) was calculated. Results Mean baseline HIV‐1 RNA was 4.2 log 10 copies/mL in group 1 and 3.8 log 10 copies/mL in group 2. After 28 days, the mean HIV‐1 RNA reduction was 0.99 log 10 copies/mL [95% confidence interval (CI) 0.45–1.53] for group 1 and 0.89 log 10 copies/mL (95% CI 0.38–1.40) for group 2. AUCMB/day values were 0.775 log 10 copies/mL (95% CI 0.33–1.22) and 0.774 log 10 copies/mL (95% CI 0.48–1.07), respectively, showing no difference in the rate of decrease of HIV‐1 RNA ( P =0.995). Mean ddI plasma levels at day 28 were 0.0234 mg/L for group 1 and 0.0227 mg/L for group 2 ( P =0.96). Conclusions In this pilot study, the administration of food did not have any significant effect on the antiviral activity of ddI‐EC capsules. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1468-1293.2008.00543.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1468-1293.2008.00543.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-1293.2008.00543.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1293.2008.00543.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.9D233D00 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1468-1293.2008.00543.x |
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