Academic Journal
Murine genetic background overcomes gut microbiota changes to explain metabolic response to high-fat diet
| العنوان: | Murine genetic background overcomes gut microbiota changes to explain metabolic response to high-fat diet |
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| المؤلفون: | Safari, Zahra, Bruneau, Aurelia, Monnoye, Magali, Mariadassou, Mahendra, Philippe, Catherine, Zatloukal, Kurt, Gerard, Philippe |
| المساهمون: | Institute of Pathology, Aarhus University Hospital, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mathématiques et Informatique Appliquées du Génome à l'Environnement Jouy-En-Josas (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris-Saclay, the FWF (W 1226, DK Metabolic and Cardiovascular Disease) at the Medical University of Graz, ANR-11-INBS-0013,IFB (ex Renabi-IFB),Institut français de bioinformatique(2011) |
| المصدر: | ISSN: 2072-6643 ; Nutrients ; https://hal.science/hal-02503303 ; Nutrients, 2020, 12 (2), ⟨10.3390/nu12020287⟩. |
| بيانات النشر: | CCSD MDPI |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | fecal microbiota transplantation (FMT), antibiotic treatment, high-fat diet (HFD), genetic background, metabolic disease, non-alcoholic fatty liver disease (NAFLD), [SDV]Life Sciences [q-bio] |
| الوصف: | Interactions of diet, gut microbiota, and host genetics play essential roles in the development of metabolic diseases. A/J and C57BL/6J (C57) are two mouse strains known to display different susceptibilities to metabolic disorders. In this context, we analyzed gut microbiota composition in A/J and C57 mice, and assessed its responses to high-fat diet (HFD) and antibiotic (AB) treatment. We also exchanged the gut microbiota between the two strains following AB treatment to evaluate its impact on the metabolism. We showed that A/J and C57 mice have different microbiome structure and composition at baseline. Moreover, A/J and C57 microbiomes responded differently to HFD and AB treatments. Exchange of the gut microbiota between the two strains was successful as recipients’ microbiota resembled donor-strain microbiota. Seven weeks after inoculation, the differences between recipients persisted and were still closer from the donor-strain microbiota. Despite effective microbiota transplants, the response to HFD was not markedly modified in C57 and A/J mice. Particularly, body weight gain and glucose intolerance in response to HFD remained different in the two mouse strains whatever the changes in microbiome composition. This indicated that genetic background has a much stronger impact on metabolic responses to HFD than gut microbiome composition. View |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31973214; PRODINRA: 496376; PUBMED: 31973214; WOS: 000522458700014 |
| DOI: | 10.3390/nu12020287 |
| الاتاحة: | https://hal.science/hal-02503303 https://hal.science/hal-02503303v1/document https://hal.science/hal-02503303v1/file/2020_Safari_nutrients.pdf https://doi.org/10.3390/nu12020287 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.9CBEE127 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu12020287 |
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