Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation.

التفاصيل البيبلوغرافية
العنوان:	Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation.
المؤلفون:	Zhang, Xiaomeng, He, Yazhou, Li, Xue, Shraim, Rasha, Xu, Wei, Wang, Lijuan, Farrington, Susan M, Campbell, Harry, Timofeeva, Maria, Zgaga, Lina, Vaughan-Shaw, Peter, Theodoratou, Evropi, Dunlop, Malcolm G
بيانات النشر:	Springer Science and Business Media LLC Department of Public Health and Primary Care, Cancer Genetic Epidemiology //doi.org/10.1038/s41416-024-02643-5 Br J Cancer
سنة النشر:	2024
المجموعة:	Apollo - University of Cambridge Repository
مصطلحات موضوعية:	Humans, Colorectal Neoplasms, Mendelian Randomization Analysis, Vitamin D, Male, Female, Prospective Studies, Middle Aged, Aged, Scotland, Proportional Hazards Models, Adult
الوصف:	BACKGROUND: To investigate the association between circulating 25-hydroxyvitamin D (25-OHD) and colorectal cancer (CRC) survival outcomes. METHODS: We conducted analyses among the Study of Colorectal Cancer in Scotland (SOCCS) and the UK Biobank (UKBB). Both cancer-specific survival (CSS) and overall survival (OS) outcomes were examined. The 25-OHD levels were categorised into three groups, and multi-variable Cox-proportional hazard models were applied to estimate hazard ratios (HRs). We performed individual-level Mendelian randomisation (MR) through the generated polygenic risk scores (PRS) of 25-OHD and summary-level MR using the inverse-variance weighted (IVW) method. RESULTS: We observed significantly poorer CSS (HR = 0.65,95%CI = 0.55-0.76,P = 1.03 × 10-7) and OS (HR = 0.66,95%CI = 0.58-0.75,P = 8.15 × 10-11) in patients with the lowest compared to those with the highest 25-OHD after adjusting for covariates. These associations remained across patients with varied tumour sites and stages. However, we found no significant association between 25-OHD PRS and either CSS (HR = 0.98,95%CI = 0.80-1.19,P = 0.83) or OS (HR = 1.07,95%CI = 0.91-1.25,P = 0.42). Furthermore, we found no evidence for causal effects by conducting summary-level MR analysis for either CSS (IVW:HR = 1.04,95%CI = 0.85-1.28,P = 0.70) or OS (IVW:HR = 1.10,95%CI = 0.93-1.31,P = 0.25). CONCLUSION: This study supports the observed association between lower circulating 25-OHD and poorer survival outcomes for CRC patients. Whilst the genotype-specific association between better outcomes and higher 25-OHD is intriguing, we found no support for causality using MR approaches.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
Relation:	https://www.repository.cam.ac.uk/handle/1810/368451
الاتاحة:	https://www.repository.cam.ac.uk/handle/1810/368451
Rights:	https://creativecommons.org/licenses/by/4.0/
رقم الانضمام:	edsbas.9CB40829
قاعدة البيانات:	BASE

View record in BASE

الوصف
الوصف غير متاح.