Image
Image3_JNK signaling and integrins cooperate to maintain cell adhesion during epithelial fusion in Drosophila.TIF
| العنوان: | Image3_JNK signaling and integrins cooperate to maintain cell adhesion during epithelial fusion in Drosophila.TIF |
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| المؤلفون: | Katerina Karkali, Jose Carlos Pastor-Pareja, Enrique Martin-Blanco |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cell Biology, Marine Biology, Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Drosophila, JNK, puckered, integrin, dorsal closure, JNK sensor |
| الوصف: | The fusion of epithelial sheets is an essential and conserved morphogenetic event that requires the maintenance of tissue continuity. This is secured by membrane-bound or diffusible signals that instruct the epithelial cells, in a coordinated fashion, to change shapes and adhesive properties and when, how and where to move. Here we show that during Dorsal Closure (DC) in Drosophila, the Jun kinase (JNK) signaling pathway modulates integrins expression and ensures tissue endurance. An excess of JNK activity, as an outcome of a failure in the negative feedback implemented by the dual-specificity phosphatase Puckered (Puc), promotes the loss of integrins [the ß-subunit Myospheroid (Mys)] and amnioserosa detachment. Likewise, integrins signal back to the pathway to regulate the duration and strength of JNK activity. Mys is necessary for the regulation of JNK activity levels and in its absence, puc expression is downregulated and JNK activity increases. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Image3_JNK_signaling_and_integrins_cooperate_to_maintain_cell_adhesion_during_epithelial_fusion_in_Drosophila_TIF/24964980 |
| DOI: | 10.3389/fcell.2023.1034484.s004 |
| الاتاحة: | https://doi.org/10.3389/fcell.2023.1034484.s004 https://figshare.com/articles/figure/Image3_JNK_signaling_and_integrins_cooperate_to_maintain_cell_adhesion_during_epithelial_fusion_in_Drosophila_TIF/24964980 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.9CAF074C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fcell.2023.1034484.s004 |
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