التفاصيل البيبلوغرافية
| العنوان: |
Analysis of bucoadhesive systems ; Análisis de sistemas bucoadhesivos. |
| المؤلفون: |
Castán Urbano, Herminia, Morales Hernández, María Encarnación, Clares Naveros, Beatriz, Calpena Campmany, Ana Cristina, Ruíz Martínez, María Adolfina |
| المصدر: |
Ars Pharmaceutica (Internet); Vol. 54 Núm. 2 (2013); 39-43 ; Ars Pharmaceutica (Internet); Vol. 54 No. 2 (2013); 39-43 ; 2340-9894 ; 0004-2927 |
| بيانات النشر: |
Editorial Universidad de Granada |
| سنة النشر: |
2013 |
| المجموعة: |
Portal de revistas de la Universidad de Granada |
| مصطلحات موضوعية: |
Bucoadhesive patch, doxepin hydrochloride, administration transbuccal, calorimetric analysis, swelling, Parche bucoadhesivo, clorhidrato de doxepina, administración transbucal, análisis calorimétrico, hinchamiento |
| الوصف: |
Aim: The aim of this study is to design a bucoadhesive patch for the transbuccal administration of doxepin hydrochloride using different polymers as well as the characterization of these systems for calorimetric analysis and the swelling capacity.Materials and methods: Doxepin hydrochloride was used as well as various polymers; carboxymethylcellulose sodium, hydroxypropylmethyl cellulose and chitosan. Differential scanning calorimetry (DSC) was carried out using a Mettler FP 80 device equipped with a FP 85 oven and the swelling capacity using agar plates.Results: Thermograms obtained patches and physical mixtures where there are endothermic transitions between 30 and 120º C and the endothermic peak of the active principle in binary physical mixtures. Dehydration enthalpy is similar in polymers of carboxymethylcellulose sodium and chitosan (281 J/g), the film having less hydroxypropylmethylcellulose (251 J/g), the percentage of moisture shows that the patches prepared with hydroxypropylmethylcellulose have less tendency to collect water (55.91 %) compared to 67.04 % and 67.30 % with sodium carboxymethylcellulose and chitosan, respectively.Conclusion: The results show that there is compatibility between the components of the formulation and the enthalpy data correlate with the data obtained in the swelling test. ; Objetivo: El objetivo de este estudio es el diseño de un parche bucoadhesivo para la administración transbucal de clorhidrato de doxepina utilizando diferentes polímeros así como la caracterización de dichos sistemas en cuanto al análisis calorimétrico y la capacidad de hinchamiento.Materiales y métodos: Se ha utilizado clorhidrato de doxepina y diferentes polímeros, carboximetilcelulosa sódica, hidroxipropilmetilcelulosa y chitosan. La calorimetría diferencial de barrido (DSC) se ha realizado en un dispositivo Mettler FP 80 equipado con un horno FP 85 y la capacidad de hinchamiento utilizando placas de agar.Resultados: Se obtienen termogramas de los parches y las mezclas físicas donde se observan ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
Spanish; Castilian |
| Relation: |
https://revistaseug.ugr.es/index.php/ars/article/view/4638/4515; https://revistaseug.ugr.es/index.php/ars/article/view/4638 |
| الاتاحة: |
https://revistaseug.ugr.es/index.php/ars/article/view/4638 |
| رقم الانضمام: |
edsbas.9CA2BF7E |
| قاعدة البيانات: |
BASE |