Academic Journal
Case report: A rare case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma incidentally diagnosed in a 15-year-old girl
| العنوان: | Case report: A rare case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma incidentally diagnosed in a 15-year-old girl |
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| المؤلفون: | Gürlüler, Ercüment |
| المساهمون: | Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, orcid:0000-0002-6008-5494, GÜRLÜLER, ERCÜMENT, X-7425-2018 |
| بيانات النشر: | Frontiers Media Sa |
| سنة النشر: | 2024 |
| المجموعة: | Açık Erişim@BUU (Bursa Uludağ Üniversitesi) |
| مصطلحات موضوعية: | Hypercalcemia, Ectopic parathyroid adenoma, Pediatric age, Persistent hypercalcemia, Persistently elevated pth, Vats thymectomy, Combined mibi plus ct, Intraoperative intact pth monitoring, Frozen section diagnosis, Science & technology, Life sciences & biomedicine, Endocrinology & metabolism |
| الوصف: | Primary hyperparathyroidism (PHPT) due to ectopic parathyroid adenoma is a rare case of hypercalcemia in the pediatric population. Herein, a rare case of PHPT due to ectopic intrathymic parathyroid adenoma was described in an asymptomatic 15-year-old girl who had incidental diagnosis based on laboratory abnormalities but experienced a 3-month postoperative course of persistently elevated parathyroid hormone (PTH) and hypercalcemia following the initial unsuccessful parathyroidectomy operation carried out in a non-parathyroid expert center. The curative surgical treatment was accomplished only after the patient was reoperated with video-assisted thoracoscopic surgery (VATS) thymectomy by the surgeon experienced in parathyroid surgery with implementation of the combined imaging modalities for accurate localization of ectopic adenoma including 99mTc sestamibi (MIBI) plus neck and thoracic computed tomography (CT) and the appropriate surgical strategies including intraoperative intact PTH monitoring and frozen section diagnosis. Before the reoperation (VATS thymectomy), laboratory findings showed elevated PTH (1,171 ng/L; reference range: 21.80 ng/L-87.5 ng/L) and hypercalcemia (13.4 mg/dL; reference range: 8.4 mg/dL-10.2 mg/dL). The preoperative PTH levels were 94 ng/L at 5 min after thymectomy and 78 ng/L at 10 min. The PTH and calcium levels were 54.3 ng/L and 8.47 mg/dL, respectively, on postoperative day 1 and were 34.2 ng/L and 8.1 mg/dL on postoperative day 2. The patient was discharged on postoperative day 2 without any complications. In conclusion, our findings indicate the likelihood of isolated primary hyperparathyroidism to be incidentally diagnosed based solely on laboratory abnormalities with no specific clinical manifestations in the pediatric age. In addition, using combined imaging modalities (such as MIBI and CT) in accurate localization of ectopic parathyroid adenoma and implementation of surgery by experienced surgeons along with intraoperative intact PTH monitoring and frozen section diagnosis ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Makale - Uluslararası Hakemli Dergi; Frontiers in Endocrinology; https://doi.org/10.3389/fendo.2024.1371098; https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1371098/full; https://hdl.handle.net/11452/49876; 001337075100001; 15 |
| DOI: | 10.3389/fendo.2024.1371098 |
| DOI: | 10.3389/fendo.2024.1371098/full |
| الاتاحة: | https://hdl.handle.net/11452/49876 https://doi.org/10.3389/fendo.2024.1371098 https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1371098/full |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9C8E5A74 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2024.1371098 |
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