Academic Journal
L1CAM is not a predictive factor in early-stage squamous-cell cervical cancer
| العنوان: | L1CAM is not a predictive factor in early-stage squamous-cell cervical cancer |
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| المؤلفون: | Romanová, Martina, Židlík, Vladimír, Javůrková, Veronika, Kondé, Adela, Šimetka, Ondřej, Klát, Jaroslav |
| بيانات النشر: | International Institute of Anticancer Research |
| سنة النشر: | 2023 |
| المجموعة: | DSpace VŠB-TUO (Vysoká škola báňská - Technická univerzita Ostrava / Technical University of Ostrava) |
| مصطلحات موضوعية: | L1 cell adhesion molecule, squamous-cell cervical carcinoma, early stage, prognostic factor |
| الوصف: | Aim: Our study aimed to assess expression of L1 cell adhesion molecule (L1CAM) in early-stage cervical squamous-cell cancer as a prognostic factor. Patients and Methods: This retrospective, single-institution study included 154 patients who underwent radical hysterectomy for early-stage squamous cell cervical cancer between 2007 and 2017. Tumor samples from 154 patients were available for L1CAM analysis by immunohistochemistry. Among all patients, radical abdominal hysterectomy was performed in 144 cases. Results: L1CAM expression was positive in 24 tumors (15.6%) of the whole group. In relation to the grade of differentiation and the presence of lymphovascular invasion, L1CAM expression did not show an association (p=0.154 and p=0.306, respectively). The disease-free interval and overall survival also did not significantly differ between L1CAM-positive and L1CAM-negative cases (p=0.427 and p=0.240, respectively). For histopathological characteristics, L1CAM-positive cases had a significantly higher median tumor size (p=0.015). Even in the selected group of 115 cases without nodal infiltration, L1CAM status had no effect on the relapse rate during follow-up. Conclusion: Our study did not confirm the results of previous studies showing L1CAM expression to be a negative prognostic factor in cervical cancer. In our study, increased L1CAM expression in early-stage squamous-cell cervical cancer was not associated with adverse prognosis regarding disease recurrence, disease-free survival, nor overall survival. L1CAM expression was correlated only with the size of the tumor. ; Web of Science ; 37 ; 5 ; 2339 ; 2334 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0258-851X 1791-7549 |
| Relation: | In Vivo; https://doi.org/10.21873/invivo.13337; In Vivo. 2023, vol. 37, issue 5, p. 2334-2339.; http://hdl.handle.net/10084/154865; 001108917300012 |
| DOI: | 10.21873/invivo.13337 |
| الاتاحة: | http://hdl.handle.net/10084/154865 https://doi.org/10.21873/invivo.13337 |
| Rights: | Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; openAccess |
| رقم الانضمام: | edsbas.9C5B0C5B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0258851X 17917549 |
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| DOI: | 10.21873/invivo.13337 |