Academic Journal
Retrospective Diagnosis of Parkinsonian Syndromes Using Whole-Brain Atrophy Rates
| العنوان: | Retrospective Diagnosis of Parkinsonian Syndromes Using Whole-Brain Atrophy Rates |
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| المؤلفون: | Carlos Guevara, Kateryna Bulatova, Wendy Soruco, Guido Gonzalez, Gonzalo A. Farías |
| المصدر: | Frontiers in Aging Neuroscience, Vol 9 (2017) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | whole brain atrophy rate, multiple system atrophy, progressive supranuclear palsy, idiopathic Parkinson's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Objective: The absence of markers for ante-mortem diagnosis of idiopathic Parkinson's disease (IPD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) results in these disorders being commonly mistaken for each other, particularly in the initial stages. We aimed to investigate annualized whole-brain atrophy rates (a-WBAR) in these disorders to aid in the diagnosis between IPD vs. PSP and MSA.Methods: Ten healthy controls, 20 IPD, 39 PSP, and 41 MSA patients were studied using Structural Imaging Evaluation with Normalization of Atrophy (SIENA). SIENA is an MRI-based algorithm that quantifies brain tissue volume and does not require radiotracers. SIENA has been shown to have a low estimation error for atrophy rate over the whole brain (0.5%).Results: In controls, the a-WBAR was 0.37% ± 0.28 (CI 95% 0.17–0.57), while in IPD a-WBAR was 0.54% ± 0.38 (CI 95% 0.32–0.68). The IPD patients did not differ from the controls. In PSP, the a-WBAR was 1.93% ± 1.1 (CI 95% 1.5–2.2). In MSA a-WBAR was 1.65% ± 0.9 (CI 95%1.37–1.93). MSA did not differ from PSP. The a-WBAR in PSP and MSA were significantly higher than in IPD (p < 0.001). a-WBAR 0.6% differentiated patients with IPD from those with PSA and MSA with 91% sensitivity and 80% specificity.Conclusions: a-WBAR within the normal range is unlikely to be observed in PSP or MSA. a-WBAR may add a potential retrospective application to improve the diagnostic accuracy of MSA and PSP vs. IPD during the first year of clinical assessment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1663-4365 |
| Relation: | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00099/full; https://doaj.org/toc/1663-4365; https://doaj.org/article/3e486be4a64947c7a37e0475737f6191 |
| DOI: | 10.3389/fnagi.2017.00099 |
| الاتاحة: | https://doi.org/10.3389/fnagi.2017.00099 https://doaj.org/article/3e486be4a64947c7a37e0475737f6191 |
| رقم الانضمام: | edsbas.9C3982E6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16634365 |
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| DOI: | 10.3389/fnagi.2017.00099 |