Academic Journal
Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for in Vitro Prodrug Activation by Modulating the Polymer’s Microstructure
| العنوان: | Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for in Vitro Prodrug Activation by Modulating the Polymer’s Microstructure |
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| المؤلفون: | Deng, Linlin, Sathyan, Anjana, Adam, Catherine, Unciti-Broceta, Asier, Sebastián, Víctor, Palmans, Anja R.A. |
| المصدر: | Deng , L , Sathyan , A , Adam , C , Unciti-Broceta , A , Sebastián , V & Palmans , A R A 2024 , ' Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for in Vitro Prodrug Activation by Modulating the Polymer’s Microstructure ' , Nano Letters , vol. 24 , no. 7 , pp. 2242-2249 . https://doi.org/10.1021/acs.nanolett.3c04466 |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Humans, Nanoparticles/chemistry, Prodrugs/chemistry, Catalysis, Antineoplastic Agents/chemistry, Hep G2 Cells, Polymers/chemistry, in vitro catalysis, compartmentalization, prodrug activation, single chain polymeric nanoparticle, nanocatalyst, bioorthogonal catalysis |
| الوصف: | Bioorthogonal catalysis employing transition metal catalysts is a promising strategy for the in situ synthesis of imaging and therapeutic agents in biological environments. The transition metal Pd has been widely used as a bioorthogonal catalyst, but bare Pd poses challenges in water solubility and catalyst stability in cellular environments. In this work, Pd(0) loaded amphiphilic polymeric nanoparticles are applied to shield Pd in the presence of living cells for the in situ generation of a fluorescent dye and anticancer drugs. Pd(0) loaded polymeric nanoparticles prepared by the reduction of the corresponding Pd(II)-polymeric nanoparticles are highly active in the deprotection of pro-rhodamine dye and anticancer prodrugs, giving significant fluorescence enhancement and toxigenic effects, respectively, in HepG2 cells. In addition, we show that the microstructure of the polymeric nanoparticles for scaffolding Pd plays a critical role in tuning the catalytic efficiency, with the use of the ligand triphenylphosphine as a key factor for improving the catalyst stability in biological environments. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1021/acs.nanolett.3c04466 |
| الاتاحة: | https://research.tue.nl/en/publications/c2ded9e3-0216-4e5b-a719-8ce3f7a94fb2 https://doi.org/10.1021/acs.nanolett.3c04466 https://pure.tue.nl/ws/files/319626983/deng-et-al-2024-enhanced-efficiency-of-pd_0_-based-single-chain-polymeric-nanoparticles-for-in-vitro-prodrug-activation.pdf http://www.scopus.com/inward/record.url?scp=85185594675&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9C333BE7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.nanolett.3c04466 |
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