Academic Journal
Diffusion tensor imaging metrics associated with future disability in multiple sclerosis
| العنوان: | Diffusion tensor imaging metrics associated with future disability in multiple sclerosis |
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| المؤلفون: | López Soley, Elisabet, Martinez-Heras, Eloy, Solana, Elisabeth, Solanes Font, Aleix, Radua, Joaquim, Vivó Sánchez, Francisco Javier, Prados, Ferran, Sepúlveda, Maria, Cabrera Maqueda, José María, Fonseca, Elianet, Blanco, Yolanda, Alba Arbalat, Salut, Martínez Lapiscina, Elena H., Villoslada, Pablo, Llufriu, Sara, Saiz Hinarejos, Albert |
| المساهمون: | Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria |
| بيانات النشر: | Springer |
| سنة النشر: | 2023 |
| المجموعة: | Universitat Politècnica de Catalunya, BarcelonaTech: UPCommons - Global access to UPC knowledge |
| مصطلحات موضوعية: | Àrees temàtiques de la UPC::Ciències de la salut::Medicina, Multiple sclerosis, Imaging systems in medicine, Anisotropy, Esclerosi múltiple, Imatgeria mèdica, Anisotropia |
| الوصف: | The relationship between brain difusion microstructural changes and disability in multiple sclerosis (MS) remains poorly understood. We aimed to explore the predictive value of microstructural properties in white (WM) and grey matter (GM), and identify areas associated with mid-term disability in MS patients. We studied 185 patients (71% female; 86% RRMS) with the Expanded Disability Status Scale (EDSS), timed 25-foot walk (T25FW), nine-hole peg test (9HPT), and Symbol Digit Modalities Test (SDMT) at two time-points. We used Lasso regression to analyse the predictive value of baseline WM fractional anisotropy and GM mean difusivity, and to identify areas related to each outcome at 4.1 years follow-up. Motor performance was associated with WM (T25FW: RMSE= 0.524, R2 = 0.304; 9HPT dominant hand: RMSE= 0.662, R2 = 0.062; 9HPT non-dominant hand: RMSE= 0.649, R2 = 0.139), and SDMT with GM difusion metrics (RMSE= 0.772, R2 = 0.186). Cingulum, longitudinal fasciculus, optic radiation, forceps minor and frontal aslant were the WM tracts most closely linked to motor dysfunction, and temporal and frontal cortex were relevant for cognition. Regional specifcity related to clinical outcomes provide valuable information that can be used to develop more accurate predictive models that could improve therapeutic strategies. ; This research was carried out at the Centre Esther Koplowitz of the IDIBAPS, Fundació Clinic per a la recerca biomèdica and Hospital Clinic Barcelona (Barcelona, Spain), which are supported by the CERCA Programme/Generalitat de Catalunya. This work was sponsored by the Instituto Carlos III (ISCIII) and co-funded by the European Union through the Plan Estatal de Investigación Científica y Técnica y de Innovación 2015-2024 (PI15/00587, PI18/01030 and PI21/01189 to SL and AS and SL; PI15/00061 to PV; and JR16/00006; MV17/00021; PI17/01228; RD16/0015/0003 to E.H.M.-L); by the Red Española de Esclerosis Múltiple (REEM: RD16/0015/0002, RD16/0015/0003, RD12/0032/0002, RD12/0060/01-02); by TEVA Spain, the Ayudas ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://www.nature.com/articles/s41598-023-30502-5; López, E. [et al.]. Diffusion tensor imaging metrics associated with future disability in multiple sclerosis. "Scientific reports", 2 Març 2023, vol. 13, núm. 1, article 3565.; http://hdl.handle.net/2117/407888 |
| DOI: | 10.1038/s41598-023-30502-5 |
| الاتاحة: | http://hdl.handle.net/2117/407888 https://doi.org/10.1038/s41598-023-30502-5 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; Open Access |
| رقم الانضمام: | edsbas.9C15AACD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-30502-5 |