Academic Journal
Val-Geninthiocin: Structure Elucidation and MS n Fragmentation of Thiopeptide Antibiotics Produced by Streptomyces sp. RSF18
| العنوان: | Val-Geninthiocin: Structure Elucidation and MS n Fragmentation of Thiopeptide Antibiotics Produced by Streptomyces sp. RSF18 |
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| المؤلفون: | Imran Sajid, Khaled A Shaaban, Holm Frauendorf, Shahida Hasnain, Hartmut Laatsch |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://znaturforsch.com/s63b/s63b1223.pdf. |
| سنة النشر: | 2008 |
| المجموعة: | CiteSeerX |
| الوصف: | Val-Geninthiocin (2), a new member of thiopeptide antibiotics, was isolated from the mycelium of Streptomyces sp. RSF18, along with the closely related geninthiocin (1) and the macrolide, chalcomycin. By intensive NMR and MS studies, Val-geninthiocin (2) was identified as desoxygeninthiocin, a thiopeptide, containing several oxazole and thiazole units and a number of unusual amino acids. Compound 2 shows potent activity against Gram-positive bacteria and minor antifungal activity, while it is not effective against Gram-negative bacteria or microalgae. Here we describe the fermentation, isolation and structure elucidation as well as the biological activity of 2. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1045.6639; http://znaturforsch.com/s63b/s63b1223.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1045.6639 http://znaturforsch.com/s63b/s63b1223.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.9BFFFF66 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |