Academic Journal
Role of TIM-1 in the development and treatment of tumours
| العنوان: | Role of TIM-1 in the development and treatment of tumours |
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| المؤلفون: | Cao, Jinmeng, Qing, Jilin, Zhu, Liya, Chen, Zhizhong |
| المصدر: | Frontiers in Cell and Developmental Biology ; volume 12 ; ISSN 2296-634X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2024 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | T-cell immunoglobulin and mucin structural domain 1 (TIM-1, also known as hepatitis A virus cell receptor 1) is a co-stimulatory molecule that is expressed predominantly on the surface of T cells. TIM-1 promotes the activation and proliferation of T cells, cytokine secretion, and can also be overexpressed in various types of cancer. Upregulation of TIM-1 expression may be associated with the development and progression of cancer. After reviewing the literature, we propose that TIM-1 affects tumour development mainly through two pathways. In the Direct pathway: overexpression in tumours activates tumour-related signaling pathways, mediates the proliferation, apoptosis, invasion and metastasis, and directly affects tumour development directly. In the indirect pathway: In addition to changing the tumour microenvironment and influencing the growth of tumours, TIM-1 binds to ligands to encourage the activation, proliferation, and generation of cytokines by immune cells. This review examines how TIM-1 stimulates the development of tumours in direct and indirect ways, and how TIM-1 is exploited as a target for cancer therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fcell.2024.1307806 |
| DOI: | 10.3389/fcell.2024.1307806/full |
| الاتاحة: | http://dx.doi.org/10.3389/fcell.2024.1307806 https://www.frontiersin.org/articles/10.3389/fcell.2024.1307806/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.9BED4205 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fcell.2024.1307806 |
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