Academic Journal
Behavioral And Neuroanatomical Outcomes Of Early And Late Preterm Hypoxic-Ischemic Injury And The Neuroprotective Effects Of Whole-Body Hypothermia: An Animal Model
| العنوان: | Behavioral And Neuroanatomical Outcomes Of Early And Late Preterm Hypoxic-Ischemic Injury And The Neuroprotective Effects Of Whole-Body Hypothermia: An Animal Model |
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| المؤلفون: | Garbus, Haley C |
| المصدر: | University Scholar Projects |
| بيانات النشر: | Digital Commons @ UConn |
| سنة النشر: | 2015 |
| المجموعة: | University of Connecticut (UConn): DigitalCommons@UConn |
| مصطلحات موضوعية: | hypoxia-ischemia, hypothermia, whole-body cooling, brain injury, rapid auditory processing, prepulse inhibition, learning and memory, spatial memory, non-spatial memory, Morris water maze, non-spatial water maze, visual attention, social preference, social recognition, ADHD, attention-deficit, autism, language delays, abnormal social behavior, preterm, low birth weight infants, early preterm, very low birth weight, anoxia, white matter, gray matter, striatum, corpus callosum, MGN, Behavioral Neurobiology |
| الوصف: | The overarching aims of this research were: first, to characterize the anatomical and behavioral effects of preterm hypoxic-ischemic (HI) injury in rodent models; and second, to explore the method of passively induced whole-body hypothermia as a neuroprotective intervention following HI. Clinical research of preterm injured infants has shown a large range of behavioral deficits, including delays in language learning, spatial and non-spatial memory, visual attention, and motor coordination. The current studies focused on these behavioral abnormalities, using HI rodent models. Specifically, we explored a model for early preterm HI (HI induced on postnatal day (P) 3 in rats), and compared it to the previous models we have used for late preterm HI (HI induced on P7), specifically using behavioral testing to characterize long-term outcomes. Additionally, the current studies sought to better characterize the language deficits associated with HI injury in humans, but using a rodent model to test the “magnocellular theory†of rapid auditory processing deficits. Research indicates that the use of cooling (both head-selective and whole body) has been shown to help reduce HI injury in both human populations and animal models. We set out to investigate how whole-body hypothermia might be used to ameliorate the behavioral deficits in an HI model, and specifically designed our focus on early preterm HI by using a P3 animal model. The overall goal of these studies was to expand upon knowledge regarding the behavioral and anatomical deficits associated with HI, and neuroprotective strategies following HI specifically, passively-induced whole-body hypothermia. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://digitalcommons.lib.uconn.edu/usp_projects/19; https://digitalcommons.lib.uconn.edu/context/usp_projects/article/1019/viewcontent/auto_convert.pdf |
| الاتاحة: | https://digitalcommons.lib.uconn.edu/usp_projects/19 https://digitalcommons.lib.uconn.edu/context/usp_projects/article/1019/viewcontent/auto_convert.pdf |
| رقم الانضمام: | edsbas.9BAC5776 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |