Academic Journal
Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of type 2 diabetic patients
| العنوان: | Postabsorptive and insulin-stimulated energy homeostasis and leucine turnover in offspring of type 2 diabetic patients |
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| المؤلفون: | G. Lattuada, L. Piceni Sereni, D. Ruggieri, A. Scollo, S. Benedini, F. Ragogna, F. Costantino, A. Battezzati, L. Luzi, G. Perseghin |
| المساهمون: | G. Lattuada, L. Piceni Sereni, D. Ruggieri, A. Scollo, S. Benedini, F. Ragogna, F. Costantino, A. Battezzati, L. Luzi, G. Perseghin |
| بيانات النشر: | American Diabetes Association |
| سنة النشر: | 2004 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Settore BIO/09 - Fisiologia |
| الوصف: | OBJECTIVE: This study was performed to ascertain whether insulin resistance with respect to protein metabolism is an additional primary metabolic abnormality affecting insulin-resistant offspring of type 2 diabetic parents, along with insulin resistance with respect to glucose and lipid metabolism. RESEARCH DESIGN AND METHODS: We studied 18 young, nonobese offspring of type 2 diabetic parents and 27 healthy matched (by means of dual-energy X-ray absorption) individuals with the bolus plus continuous infusion of [6,6-(2)H(2)]glucose and [1-(13)C]leucine in combination with the insulin clamp (40 mU x m(-2) x min(-1)). RESULTS: Fasting plasma leucine, phenylalanine, alanine, and glutamine concentrations, as well as the glucose and leucine turnover (reciprocal pool model: 155 +/- 10 vs. 165 +/- 5 micromol x kg lean body mass(-1) x h(-1) in offspring of type 2 diabetic patients and healthy matched individuals, respectively), were also not different. During the clamp, glucose turnover rates were significantly reduced in offspring of type 2 diabetic patients (7.1 +/- 0.5) in comparison with healthy matched individuals (9.9 +/- 0.6 mg x kg lean body mass(-1) x min(-1); P < 0.01). Also, the suppression of leucine turnover was impaired in offspring of type 2 diabetic patients (12 +/- 1%) in comparison with healthy matched individuals (17 +/- 1%; P = 0.04) and correlated with the degree of the impairment of insulin-stimulated glucose metabolism (R(2) = 0.13; P = 0.02). CONCLUSIONS: Nonobese, nondiabetic, insulin-resistant offspring of type 2 diabetic patients were characterized by an impairment of insulin-dependent suppression of protein breakdown, which was proportional to the impairment of glucose metabolism. These results demonstrate that in humans, a primary in vivo impairment of insulin action affects glucose and fatty acid metabolism as previously shown and also protein/amino acid metabolism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/15505010; info:eu-repo/semantics/altIdentifier/wos/WOS:000224825800023; volume:27; issue:11; firstpage:2716; lastpage:2722; journal:DIABETES CARE; http://hdl.handle.net/2434/26395; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-7444247829; http://care.diabetesjournals.org/cgi/reprint/27/11/2716 |
| DOI: | 10.2337/diacare.27.11.2716 |
| الاتاحة: | http://hdl.handle.net/2434/26395 https://doi.org/10.2337/diacare.27.11.2716 http://care.diabetesjournals.org/cgi/reprint/27/11/2716 |
| رقم الانضمام: | edsbas.9BA7B868 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2337/diacare.27.11.2716 |
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