Academic Journal
Aberrant leukocyte telomere length in Birdshot Uveitis
| العنوان: | Aberrant leukocyte telomere length in Birdshot Uveitis |
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| المؤلفون: | Vazirpanah, N. (Nadia), Verhagen, F.H. (Fleurieke H.), Rothová, A. (Aniki), Missotten, T. (Tom), Velthoven, M.E. (Mirjam ) van, Hollander, A.I. (Anneke), Hoyng, C.B. (Carel), Radstake, T.R.D.J. (Timothy), Broen, J. (Jasper), Kuiper, J.J.W. (Jonas) |
| المصدر: | PLoS ONE vol. 12 no. 5 |
| سنة النشر: | 2017 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| الوصف: | Purpose: Birdshot Uveitis (BU) is an archetypical chronic inflammatory eye disease, with poor visual prognosis, that provides an excellent model for studying chronic inflammation. BU typically affects patients in the fifth decade of life. This suggests that it may represent an age-related chronic inflammatory disease, which has been linked to increased erosion of telomere length of leukocytes. Methods: To study this in detail, we exploited a sensitive standardized quantitative real-time polymerase chain reaction to determine the peripheral blood leukocyte telomere length (LTL) in 91 genotyped Dutch BU patients and 150 unaffected Dutch controls. Results: Although LTL erosion rates were very similar between BU patients and healthy controls, we observed that BU patients displayed longer LTL, with a median of log (LTL) = 4.87 (= 74131 base pair) compared to 4.31 (= 20417 base pair) in unaffected controls (P<0.0001). The cause underpinning the difference in LTL could not be explained by clinical parameters, immune cell-subtype distribution, nor genetic predisposition based upon the computed weighted genetic risk score of genotyped validated variants in TERC, TERT, NAF1, OBFC1 and RTEL1. Conclusions: These findings suggest that BU is accompanied by significantly longer LTL. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://repub.eur.nl/pub/99798; urn:hdl:1765/99798 |
| DOI: | 10.1371/journal.pone.0176175 |
| الاتاحة: | http://repub.eur.nl/pub/99798 https://doi.org/10.1371/journal.pone.0176175 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9BA3459E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0176175 |
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