Academic Journal
Phase-Based Cortical Synchrony Is Affected by Prematurity
| العنوان: | Phase-Based Cortical Synchrony Is Affected by Prematurity |
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| المؤلفون: | Yrjola, Pauliina, Stjerna, Susanna, Palva, J. Matias, Vanhatalo, Sampsa, Tokariev, Anton |
| المساهمون: | Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Aalto University |
| بيانات النشر: | OXFORD UNIV PRESS INC |
| سنة النشر: | 2022 |
| المجموعة: | Aalto University Publication Archive (Aaltodoc) / Aalto-yliopiston julkaisuarkistoa |
| مصطلحات موضوعية: | brain networks, neonatal EEG, neurodevelopment, phase coupling, preterm infant, FUNCTIONAL CONNECTIVITY, PRETERM INFANTS, TERM, MEG, PATHWAYS, INDEX, AGE |
| الوصف: | Inter-areal synchronization by phase-phase correlations (PPCs) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography to examine brain-wide cortical PPC networks at term-equivalent age, comparing human infants after early prematurity to a cohort of healthy controls. We found that prematurity affected these networks in a sleep state-specific manner, and the differences between groups were also frequency-selective, involving brain-wide connections. The strength of synchronization in these networks was predictive of clinical outcomes in the preterm infants. These findings show that prematurity affects PPC networks in a clinically significant manner, suggesting early functional biomarkers of later neurodevelopmental compromise that may be used in clinical or translational studies after early neonatal adversity. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 2265-2276; application/pdf |
| اللغة: | English |
| Relation: | Cerebral Cortex; Volume 32, issue 10; PURE LINK: http://www.scopus.com/inward/record.url?scp=85127123388&partnerID=8YFLogxK; PURE FILEURL: https://research.aalto.fi/files/83639083/Phase_Based_Cortical_Synchrony_Is_Affected_by_Prematurity.pdf; https://aaltodoc.aalto.fi/handle/123456789/114787 |
| DOI: | 10.1093/cercor/bhab357 |
| الاتاحة: | https://aaltodoc.aalto.fi/handle/123456789/114787 https://doi.org/10.1093/cercor/bhab357 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.9B5FE747 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cercor/bhab357 |
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