التفاصيل البيبلوغرافية
| العنوان: |
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma |
| المؤلفون: |
Choi, Jee-Eun, Sebastian, Carlos, Ferrer, Christina M., Lewis, Caroline A., Sade Feldman, Moshe, LaSalle, Thomas, Gonye, Anna, Lopez, Begona G. C., Abdelmoula, Walid M., Regan, Michael S., Cetinbas, Murat, Pascual, Gloria, Wojtkiewicz, Gregory R., Silveira, Giorgia G., Boon, Ruben, Ross, Kenneth N., Tirosh, Itary, Saladi, Srinivas V., Ellisen, Leif W., Sadreyev, Ruslan I., Aznar Benitah, Salvador, Agar, Nathalie Y. R., Hacohen, Nir, Mostoslavsky, Raúl |
| المصدر: |
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
| بيانات النشر: |
Springer Nature |
| سنة النشر: |
2021 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Càncer de coll, Càncer de cap, Proliferació cel·lular, Neck cancer, Head cancer, Cell proliferation |
| الوصف: |
Head and neck squamous cell carcinoma (SCC) remains among the most aggressive human cancers. Tumour progression and aggressiveness in SCC are largely driven by tumour-propagating cells (TPCs). Aerobic glycolysis, also known as the Warburg effect, is a characteristic of many cancers; however, whether this adaptation is functionally important in SCC, and at which stage, remains poorly understood. Here, we show that the NAD+-dependent histone deacetylase sirtuin 6 is a robust tumour suppressor in SCC, acting as a modulator of glycolysis in these tumours. Remarkably, rather than a late adaptation, we find enhanced glycolysis specifically in TPCs. More importantly, using single-cell RNA sequencing of TPCs, we identify a subset of TPCs with higher glycolysis and enhanced pentose phosphate pathway and glutathione metabolism, characteristics that are strongly associated with a better antioxidant response. Together, our studies uncover enhanced glycolysis as a main driver in SCC, and, more importantly, identify a subset of TPCs as the cell of origin for the Warburg effect, defining metabolism as a key feature of intra-tumour heterogeneity. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2522-5812 |
| Relation: |
Versió postprint del document publicat a: https://doi.org/10.1038/s42255-021-00350-6; Nature Metabolism, 2021, Vol. 3, num. 2, p. 182-195; https://doi.org/10.1038/s42255-021-00350-6; http://hdl.handle.net/2445/176712; 6479539 |
| الاتاحة: |
http://hdl.handle.net/2445/176712 |
| Rights: |
(c) Springer Nature, 2021 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.9B4211E3 |
| قاعدة البيانات: |
BASE |