Academic Journal
THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
| العنوان: | THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE |
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| المؤلفون: | Valérie Urbach, Gerard Higgins, Paul Buchanan, Fiona Ringholz |
| المصدر: | Computational and Structural Biotechnology Journal, Vol 6, Iss 7 (2013) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biotechnology, TP248.13-248.65 |
| الوصف: | In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl− secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and progressive lung destruction. Beyond this general description, the pathogenesis of CF lung disease remains obscure due to an incomplete understanding of normal innate airway defense. This mini-review aims to highlight the role of the pro-resolution lipid mediator, Lipoxin A4, which is inadequately produced in CF, on several aspects of innate immunity that are altered in CF airway disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2001-0370 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2001037014601276; https://doaj.org/toc/2001-0370; https://doaj.org/article/caf0734f4a3e44feb70a20fb8b2fd923 |
| DOI: | 10.5936/csbj.201303018 |
| الاتاحة: | https://doi.org/10.5936/csbj.201303018 https://doaj.org/article/caf0734f4a3e44feb70a20fb8b2fd923 |
| رقم الانضمام: | edsbas.9B2D37C7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20010370 |
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| DOI: | 10.5936/csbj.201303018 |