Academic Journal
e0396 Clinical analysis of 30 individuals with micro CK type 1
| العنوان: | e0396 Clinical analysis of 30 individuals with micro CK type 1 |
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| المؤلفون: | Dong, Zhi-Yuan, Wang, Zhi-kai, Liu, Ji-Yong, Tang, Xiao-Bin, Wang, Li-Mei, Shi, Lian-Yi, Liu, Yuan-Ying, Zhao, Xiu-Zhen |
| بيانات النشر: | British Medical Journal Publishing Group |
| سنة النشر: | 2010 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | GWICC Abstracts 2010 |
| الوصف: | Objective The aim of the prospective study was to investigate the clinical and laboratory features of individuals with micro creatine kinase type 1 (MCK-1), and to evaluate the clinical significance of these cases who expressed serum MCK-1. Methods To screen MCK-1individuals from serum samples in our biochemistry laboratory from April 2002 to April 2010 according to both increasing CK-MB activity and CK-MB/CKratio over 25%, and finally confirmed by agarose gel electrophoresis of CK isoenzyme analysis. To analyse the clinical and laboratory data of individuals who expressed serum MCK-1 isoenzyme. Results MCK-1 was detected in the samples from 30 subjects. Their mean age at the initial presentation was 58.6 years (range 26 to 81), 63.3% were female (n=19), and 39.3% (n=11) had hypertension.of the 30 subjects, 10 (33.3%) had increased total CK activity, and 7 (23.3%) showed the abnormal phenomenon that CK-MB:CK ratio was >1. Our study indicated that the misdiagnostic rate was 40.0 % (n=12), and the rate of missed diagnosis was 46.7% (n=14). There were 3 deaths during the follow-up period. Conclusion MCK-1 was not rare in clinical practice. Among the conditions in which CK-MB activity is elevated in the absence of myocardial injury or infarction using immunoinhibition methods, MCK-1 merits special attention from clinicians. CK-MB index is a simple and rapid screening test for MCK-I. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://heart.bmj.com/cgi/content/short/96/Suppl_3/A123; http://dx.doi.org/10.1136/hrt.2010.208967.396 |
| DOI: | 10.1136/hrt.2010.208967.396 |
| الاتاحة: | http://heart.bmj.com/cgi/content/short/96/Suppl_3/A123 https://doi.org/10.1136/hrt.2010.208967.396 |
| Rights: | Copyright (C) 2010, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.9B06C67B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/hrt.2010.208967.396 |
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