Academic Journal
Evaluation of the in vitro and in vivo antihypertensive effect and antioxidant activity of blue corn hydrolysates derived from wet-milling//Evaluación del efecto antihipertensivo in vitro e in vivo y actividad antioxidante del hidrolizado de maíz azul derivado de la molienda húmeda
| العنوان: | Evaluation of the in vitro and in vivo antihypertensive effect and antioxidant activity of blue corn hydrolysates derived from wet-milling//Evaluación del efecto antihipertensivo in vitro e in vivo y actividad antioxidante del hidrolizado de maíz azul derivado de la molienda húmeda |
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| المؤلفون: | Montoya-Rodríguez, Alvaro, Osuna-Gallardo, Evelyn Isabel, Cabrera-Chávez, Francisco, Milán-Carrillo, Jorge, Reyes-Moreno, Cuauhtémoc, Milán-Noris, Evelia María, Cuevas-Rodríguez, Edith Oliva, Mora-Rochín, Saraid |
| المصدر: | Biotecnia; Vol. 22 No. 2 (2020): Mayo-Agosto; 155-162 ; Biotecnia; Vol. 22 Núm. 2 (2020): Mayo-Agosto; 155-162 ; 1665-1456 |
| بيانات النشر: | Universidad de Sonora |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | blue corn, wet-milling, corn gluten meal, antihypertensive, antioxidant activity |
| الوصف: | Hypertension is considered a risk factor for coronary heart disease, and its prevalence has increased substantially. Inhibition of angiotensin-converting enzyme (ACE-I) is key to lower blood pressure, making it an excellent treatment for hypertension. Corn (Zea mays L.) is an important source of bioactive peptides with potential anti-hypertensive activity related to ACE-I inhibition. These peptides can be obtained through the hydrolysis of corn gluten meal (CGM), as wetmilling by-products. The aim was to evaluate the in vitro and in vivo ACE-I inhibitory activity of blue CGM hydrolysates. Enzymatic digestion in vitro of blue CGM was conducted at different times. Hydrolysis for 360 min significantly increased both soluble protein and antioxidant activity by 4 and 8-fold respectively, the maximum ACE-I inhibition (94.3 %) was observed with 260 min hydrolysate. Mice were treated with the blue CGM hydrolysate (260 min), captopril or PBS to test the bioavailability in vivo. The CGM hydrolysate was detected in serum after 5 and up to 30 min after ingestion, showing the maximum ACE-I inhibitory capacity (59 %) during the first 15 min. Overall, this work showed that the blue CGM hydrolysate could serve as a functional food ingredient with antihypertensive effect due to its blood pressure-lowering peptides.RESUMENLa hipertensión es factor de riesgo en enfermedades coronarias, y su prevalencia ha aumentado sustancialmente. La inhibición de enzima convertidora de angiotensina (ECA) es clave para disminuir presión arterial, y excelente tratamiento para hipertensión. El maíz (Zea mays L.) es fuente de péptidos bioactivos con actividad antihipertensiva por inhibición de ECA. Péptidos pueden obtenerse por hidrólisis de harina de gluten de maíz (HGM), como subproducto de molienda húmeda. El objetivo fue evaluar in vitro e in vivo actividad inhibitoria de ECA en hidrolizados de HGM azul. La digestión enzimática in vitro de HGM fue conducida a diferentes tiempos. La hidrólisis por 360 min aumento significativamente proteína ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/xml |
| اللغة: | English |
| Relation: | https://biotecnia.unison.mx/index.php/biotecnia/article/view/1257/395; https://biotecnia.unison.mx/index.php/biotecnia/article/view/1257/441; https://biotecnia.unison.mx/index.php/biotecnia/article/view/1257 |
| DOI: | 10.18633/biotecnia.v22i2.1257 |
| الاتاحة: | https://biotecnia.unison.mx/index.php/biotecnia/article/view/1257 https://doi.org/10.18633/biotecnia.v22i2.1257 |
| Rights: | Derechos de autor 2020 Biotecnia |
| رقم الانضمام: | edsbas.9AD84A32 |
| قاعدة البيانات: | BASE |
| DOI: | 10.18633/biotecnia.v22i2.1257 |
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