Academic Journal

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients

التفاصيل البيبلوغرافية
العنوان: Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients
المؤلفون: Emanuele La Corte, Michele Dei Cas, Alberto Raggi, Monica Patanè, Morgan Broggi, Silvia Schiavolin, Chiara Calatozzolo, Bianca Pollo, Carlotta Pipolo, Maria Grazia Bruzzone, Giuseppe Campisi, Rita Paroni, Riccardo Ghidoni, Paolo Ferroli
المصدر: International Journal of Molecular Sciences; Volume 20; Issue 18; Pages: 4480
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2019
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: cancer, ceramides, chordoma, dihydroceramides, lipid targets, skull base, sphingolipids
جغرافية الموضوع: agris
الوصف: Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Methods: Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were conducted. Results: Analyzing the association between ceramides level and MIB-1, total ceramides and dihydroceramides showed a strong association (r = 0.7257 and r = 0.6733, respectively) with MIB-1 staining (p = 0.0033 and p = 0.0083, respectively). Among the single ceramide species, Cer C24:1 (r = 0.8814, p ≤ 0.0001), DHCer C24:1 (r = 0.8429, p = 0.0002) and DHCer C18:0 (r = 0.9426, p ≤ 0.0001) showed a significant correlation with MIB-1. Conclusion: Our lipid analysis showed ceramides to be promising tumoral biomarkers in skull base chordomas. Long- and very-long-chain ceramides, such as Cer C24:1 and DHCer C24:1, may be related to a prolonged tumor survival and aggressiveness, and the understanding of their effective biological role will hopefully shed light on the mechanisms of chordoma radio-resistance, tendency to recur, and use of agents targeting ceramide metabolism.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
Relation: Molecular Oncology; https://dx.doi.org/10.3390/ijms20184480
DOI: 10.3390/ijms20184480
الاتاحة: https://doi.org/10.3390/ijms20184480
Rights: https://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.9AD3D158
قاعدة البيانات: BASE