Academic Journal
Elevated interferon‐stimulated gene transcription in peripheral blood mononuclear cells occurs in patients infected with genotype 1 but not genotype 3 hepatitis C virus
| العنوان: | Elevated interferon‐stimulated gene transcription in peripheral blood mononuclear cells occurs in patients infected with genotype 1 but not genotype 3 hepatitis C virus |
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| المؤلفون: | Robinson, M. W., Swann, R., Sigruener, A., Barclay, S. T., Mills, P. R., McLauchlan, J., Patel, A. H. |
| المساهمون: | UK Medical Research Council, European Community's Seventh Framework Programme |
| المصدر: | Journal of Viral Hepatitis ; volume 22, issue 4, page 384-390 ; ISSN 1352-0504 1365-2893 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Hepatitis C virus ( HCV ) can be classified into seven distinct genotypes that are associated with differing pathologies and respond differently to antiviral therapy. In the UK , genotype 1 and 3 are present in approximately equal proportions. Chronic infection with HCV genotype 3 is associated with increased liver steatosis and reduced peripheral total cholesterol levels, which potentially influences peripheral immune responses. To understand these differences, we investigated host gene transcription in peripheral blood mononuclear cells by microarray and quantitative PCR in patients with genotype 1 ( n = 22) or genotype 3 infection ( n = 22) and matched healthy controls ( n = 15). Enrichment of genes involved in immune response and inflammatory pathways were present in patients infected with HCV genotype 1; however, no differences in genes involved in lipid or cholesterol metabolism were detected. This genotype‐specific induction of genes is unrelated to IL 28B genotype or previous treatment failure. Our data support the hypothesis that genotype 1 infection drives a skewed Type I interferon response and provides a foundation for future investigations into the host–pathogen interactions that underlie the genotype‐specific clinical outcomes of chronic HCV infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/jvh.12310 |
| الاتاحة: | http://dx.doi.org/10.1111/jvh.12310 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjvh.12310 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jvh.12310 |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| رقم الانضمام: | edsbas.9AD1664C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jvh.12310 |
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