Academic Journal
Ex Situ Left Ventricular Pressure-Volume Loop Analyses for Donor Hearts:Proof of Concept in an Ovine Experimental Model
| العنوان: | Ex Situ Left Ventricular Pressure-Volume Loop Analyses for Donor Hearts:Proof of Concept in an Ovine Experimental Model |
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| المؤلفون: | Ertugrul, I. A., Puspitarani, R. A.D.A., Wijntjes, B., Vervoorn, M. T., Ballan, E. M., van der Kaaij, N. P., van Goor, H., Westenbrink, B. D., van der Plaats, A., Nijhuis, F., van Suylen, V., Erasmus, M. E. |
| المصدر: | Ertugrul , I A , Puspitarani , R A D A , Wijntjes , B , Vervoorn , M T , Ballan , E M , van der Kaaij , N P , van Goor , H , Westenbrink , B D , van der Plaats , A , Nijhuis , F , van Suylen , V & Erasmus , M E 2024 , ' Ex Situ Left Ventricular Pressure-Volume Loop Analyses for Donor Hearts : Proof of Concept in an Ovine Experimental Model ' , Transplant International , vol. 37 , 12982 . https://doi.org/10.3389/ti.2024.12982 |
| سنة النشر: | 2024 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | donation after circulatory death (DCD), ex situ heart perfusion, functional evaluation, heart transplantation, viability assessment |
| الوصف: | Ex situ heart perfusion (ESHP) has emerged as an important strategy to preserve donation after brain death (DBD) and donation after circulatory death (DCD) donor hearts. Clinically, both DBD and DCD hearts are successfully preserved using ESHP. Viability assessment is currently based on biochemical values, while a reliable method for graft function assessment in a physiologic working mode is unavailable. As functional assessment during ESHP has demonstrated the highest predictive value of outcome post-transplantation, this is an important area for improvement. In this study, a novel method for ex situ assessment of left ventricular function with pressure-volume loop analyses is evaluated. Ovine hearts were functionally evaluated during normothermic ESHP with the novel pressure-volume loop system. This system provides an afterload and adjustable preload to the left ventricle. By increasing the preload and measuring end-systolic elastance, the system could successfully assess the left ventricular function. End-systolic elastance at 60 min and 120 min was 2.8 ± 1.8 mmHg/mL and 2.7 ± 0.7 mmHg/mL, respectively. In this study we show a novel method for functional graft assessment with ex situ pressure-loop analyses during ESHP. When further validated, this method for pressure-volume assessments, could be used for better graft selection in both DBD and DCD donor hearts. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3389/ti.2024.12982 |
| الاتاحة: | https://hdl.handle.net/11370/e0cc87d8-d9e9-4f50-bdbc-bdf1e8974771 https://research.rug.nl/en/publications/e0cc87d8-d9e9-4f50-bdbc-bdf1e8974771 https://doi.org/10.3389/ti.2024.12982 https://pure.rug.nl/ws/files/1134446600/Ex_Situ_Left_Ventricular_Pressure-Volume_Loop_Analyses_for_Donor_Hearts-_Proof_of_Concept_in_an_Ovine_Experimental_Model.pdf http://www.scopus.com/inward/record.url?scp=85199334292&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9ABDBF39 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/ti.2024.12982 |
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