Academic Journal
The effect of oral omeprazole on the disposition of lignocaine
| العنوان: | The effect of oral omeprazole on the disposition of lignocaine |
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| المؤلفون: | NOBLE, D. W., BANNISTER, J., LAMONT, M., ANDERSSON, T., SCOTT, D. B. |
| المصدر: | Anaesthesia ; volume 49, issue 6, page 497-500 ; ISSN 0003-2409 1365-2044 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1994 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary The effects of the gastric antisecretory drug, omeprazole, on the disposition of lignocaine were studied in 10 healthy male volunteers in a double‐blind, randomised, placebo‐controlled, two‐period crossover trial. Omeprazole 40 mg or placebo was taken daily for one week before administration of lignocaine 1 mg.kg ‐1 (3.7 μmol.kg ‐1 ) given intravenously over 10 min. Venous concentrations of lignocaine and its metabolite monoethylglycinexylidine were measured in plasma with reversed phase liquid chromatography. The mean (95% CI) areas under the curve at infinity for lignocaine after pretreatment with omeprazole or placebo were 6.67 (4.90–8.45) μmol.h.l ‐1 and 6.14 (5.05‐7.23) μmol.h.l ‐1 , respectively (p = 0.44). The respective areas for monoethylglycinexylidine were 1.85 (1.25‐2.45) μmol.h.l ‐1 and 1.79 (1.44‐2.14) μmol.h.r ‐1 (p = 0.78). Similarly, omeprazole had no significant effect on the half‐lives of lignocaine or methylglycinexylidine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-2044.1994.tb03519.x |
| DOI: | 10.1111/j.1365-2044.1994.tb03519.x/fullpdf |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-2044.1994.tb03519.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2044.1994.tb03519.x http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2044.1994.tb03519.x/fullpdf |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.9AA0F80B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-2044.1994.tb03519.x |
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